Kokosharov T, Todorova T
Vet Med Nauki. 1987;24(5):70-4.
The dynamic was followed up of the concentration of iron in the blood serum and the liver, of the erythrocyte count, of the haematocrit value of blood, and of the haemoglobin level in chickens of the New Hampshire breed at the age of 300 days, with experimentally induced acute typhoid. It was found that blood serum iron dropped abruptly as early as the second day of infection, whereas the level of iron in the liver rose. The erythrocyte count dropped almost twice as early as the second day following infection, the haematocrit value of the blood following the fluctuations of the erythrocyte count. The haemoglobin level dropped considerably on the third day, with gradually lowering values up to the seventh day. All changes that were recorded with these indices of the blood were found to precede the onset of the first clinical signs of the disease. The values of the haematologic indices with birds that survived came back to normal after the fourteenth day of infection. In the author's personal view leading in the pathogenesis of acute typhoid with the New Hampshire chickens was the lowered amount of serum iron, which disturbed the synthesis of haemoglobin and hence the maturity of erythrocytes, substantiating their lower count. The trophism of vitally important organs and tissues was also found to be disturbed.
对300日龄新罕布什尔品种鸡实验性诱发急性伤寒后，跟踪观察了血清和肝脏中铁的浓度、红细胞计数、血液血细胞比容值以及血红蛋白水平的动态变化。结果发现，早在感染第二天血清铁就急剧下降，而肝脏中铁的水平上升。红细胞计数早在感染后第二天就几乎下降了一半，血液血细胞比容值随红细胞计数波动。血红蛋白水平在第三天大幅下降，直至第七天逐渐降低。血液这些指标记录的所有变化均早于该病首个临床症状的出现。存活鸡的血液学指标值在感染后第十四天恢复正常。作者个人认为，新罕布什尔鸡急性伤寒发病机制中起主导作用的是血清铁含量降低，这干扰了血红蛋白的合成，进而影响红细胞成熟，证实红细胞数量减少。还发现重要器官和组织的营养状况也受到干扰。
