Yuan Bingqian, Lu Xiaoyu, Yang Min, He Qiyi, Cha Zhuocen, Fang Yaqun, Yang Yan, Xu Lei, Yan Jingting, Lai Ren, Wang Aili, Yu Xiaodong, Duan Zilei
School of Life Sciences, Tianjin University, Tianjin, China.
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Sino-African Joint Research Center, and Engineering Laboratory of Peptides, Kunming Institute of Zoology, Kunming, China.
Front Microbiol. 2022 Oct 10;13:1029366. doi: 10.3389/fmicb.2022.1029366. eCollection 2022.
() is a Gram-positive pathogenic bacterium, which persistently colonizes the anterior nares of approximately 20-30% of the healthy adult population, and up to 60% is intermittently colonized. With the misuse and overuse of antibiotics, large-scale drug-resistant bacteria, including methicillin-resistant (MRSA), have been appeared. MRSA is among the most prevalent pathogens causing community-associated infections. Once out of control, the number of deaths caused by antimicrobial resistance may exceed 10 million annually by 2050. Antimicrobial peptides (AMPs) are regarded as the best solution, for they are not easy to develop drug resistance. Based on our previous research, here we designed a new antimicrobial peptide named GW18, which showed excellent antimicrobial activity against , even MRSA, with the hemolysis less than 5%, no cytotoxicity, and no acute toxicity. Notably, administration of GW18 significantly decreased infection in mouse model. These findings identify GW18 as the ideal candidate against infection.
（某细菌名称）是一种革兰氏阳性病原菌，它持续定植于约20%-30%健康成年人群的前鼻孔，高达60%的人群会间歇性定植。随着抗生素的滥用和过度使用，包括耐甲氧西林（某细菌名称）（MRSA）在内的大规模耐药菌已经出现。MRSA是引起社区获得性感染的最常见病原体之一。一旦失控，到2050年，抗菌药物耐药性导致的死亡人数每年可能超过1000万。抗菌肽（AMPs）被认为是最佳解决方案，因为它们不容易产生耐药性。基于我们之前的研究，我们在此设计了一种名为GW18的新型抗菌肽，它对（某细菌名称）甚至MRSA都表现出优异的抗菌活性，溶血率低于5%，无细胞毒性，也无急性毒性。值得注意的是，在小鼠模型中给予GW18可显著降低（某细菌名称）感染。这些发现确定GW18是对抗（某细菌名称）感染的理想候选物。
