Vo Kristine, Nishimura Yoshito, Yokoyama Jennifer, Wasko Amanda, Miyake Taryn, Vu Kimberly, Zhang James, Pino Moreno Jesus, Banerjee Dipanjan, Kim Lisa, Chong Christina
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Queen's Heart Institute, The Queen's Medical Center, Honolulu, Hawaii, USA.
Eur J Case Rep Intern Med. 2022 Sep 20;9(9):003564. doi: 10.12890/2022_003564. eCollection 2022.
Eosinophilic myocarditis (EM) is a rare cause of acute heart failure. It can occur secondary to drug hypersensitivity, autoimmune diseases such as vasculitis, idiopathic hypereosinophilic syndrome (HES) or malignancy, but is often under-recognized and underdiagnosed, being confused with other causes of heart failure. While EM is associated with various clinical symptoms, it is rarely associated with cardiac tamponade that requires urgent pericardiocentesis. Here we describe a patient with EM who presented with cardiac tamponade and decompensated heart failure likely secondary to autoimmune disease.
Work-up for hypereosinophilia should include the identification of treatable causes as well as end-organ dysfunction requiring urgent treatment.In patients presenting with acute heart failure and cardiac tamponade of unclear aetiology, eosinophilic myocarditis should be considered whether or not hypereosinophilia is present on presentation.When invoking the diagnosis of eosinophilic myocarditis, extensive efforts should be made to identify primary causes, such as autoimmune conditions including vasculitis.
嗜酸性粒细胞性心肌炎(EM)是急性心力衰竭的罕见病因。它可继发于药物超敏反应、自身免疫性疾病(如血管炎)、特发性嗜酸性粒细胞增多综合征(HES)或恶性肿瘤,但常未得到充分认识和诊断,易与其他心力衰竭病因相混淆。虽然EM与多种临床症状相关,但很少与需要紧急心包穿刺的心脏压塞相关。在此,我们描述一名患有EM的患者,其出现心脏压塞和失代偿性心力衰竭,可能继发于自身免疫性疾病。
对嗜酸性粒细胞增多症的检查应包括确定可治疗的病因以及需要紧急治疗的终末器官功能障碍。对于病因不明的急性心力衰竭和心脏压塞患者,无论就诊时是否存在嗜酸性粒细胞增多,都应考虑嗜酸性粒细胞性心肌炎。在诊断嗜酸性粒细胞性心肌炎时,应做出广泛努力以确定主要病因,如包括血管炎在内的自身免疫性疾病。