Cardiology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Cardiology, Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Autoimmun Rev. 2022 Apr;21(4):103037. doi: 10.1016/j.autrev.2022.103037. Epub 2022 Jan 5.
Many systemic immune-mediated diseases (SIDs) may involve the heart and present as myocarditis with different histopathological pictures, i.e. lymphocytic, eosinophilic, granulomatous, and clinical features, ranging from a completely asymptomatic patient to life-threatening cardiogenic shock or arrhythmias. Myocarditis can be part of some SIDs, such as sarcoidosis, systemic lupus erythematosus, systemic sclerosis, antiphospholipid syndrome, dermato-polymyositis, eosinophilic granulomatosis with polyangiitis and other vasculitis syndromes, but also of some organ-based immune-mediated diseases with systemic expression, such as chronic inflammatory bowel diseases. The aim of this review is to describe the prevalence, main clinical characteristics and prognosis of myocarditis associated with SIDs.
许多系统性免疫介导性疾病（SIDs）可能累及心脏，表现为心肌炎，具有不同的组织病理学表现，即淋巴细胞性、嗜酸性粒细胞性、肉芽肿性和临床表现，从完全无症状的患者到危及生命的心源性休克或心律失常不等。心肌炎可能是某些 SIDs 的一部分，如结节病、系统性红斑狼疮、系统性硬皮病、抗磷脂综合征、皮肌炎、嗜酸性粒细胞性肉芽肿伴多血管炎和其他血管炎综合征，但也可能是某些具有全身表现的器官特异性免疫介导性疾病，如慢性炎症性肠病。本文旨在描述与 SIDs 相关的心肌炎的患病率、主要临床特征和预后。
