Kartufan Fatma F, Yildirim Alpaslan, Morkoc Okan, Çiçek Müslüm
Anesthesiology and Reanimation, Istinye University Medical Park Gaziosmanpasa Hospital, Istanbul, TUR.
Otolaryngology, Finest Private Clinic, Istanbul, TUR.
Cureus. 2022 Sep 22;14(9):e29448. doi: 10.7759/cureus.29448. eCollection 2022 Sep.
Background In this retrospective study, we aimed to investigate the effect of chlorhexidine digluconate-flurbiprofen spray (Klorhex Plus® oral spray) on postoperative sore throat (POST) and hoarseness (POH) in patients undergoing rhinoplasty. Methodology Patients who underwent rhinoplasty alone in our clinic between April 01, 2021, and February 28, 2022, were enrolled in the study. Patients' demographics such as age, gender, height, and smoking status that could affect sore throat, difficult intubation, and operation time were recorded from the patients' files. Patients were grouped as those who received Klorhex Plus oral spray before the surgery (Klorhex P group) and those who did not (control group). POST and POH were recorded from the patients' postoperative surgery files. Postoperative pain evaluation was performed using the Numerical Rating Scale (NRS) at the postoperative first hour (PPL1h), 12th hour (PPL12h), and first day (PPL1d) from the postoperative nursing files. Results A total of 354 patients who underwent rhinoplasty alone were included in this study. No significant difference was found between the groups in terms of the demographic data. Statistically, PPL1h, PPL12h, and PPL1d were significantly lower in the Klorhex P group compared to the control group (for all, p < 0.001). POST and POH were also significantly higher in the control group (both, p < 0.001). Conclusions The results of this study indicate that Klorhex Plus oral spray is an efficient agent for preemptive analgesia before rhinoplasty. It significantly decreases the postoperative pain level, POST, and POH. However, further comprehensive prospective studies are needed to introduce Klorhex Plus oral spray to rhinology practice.
背景 在这项回顾性研究中，我们旨在调查葡萄糖酸氯己定-氟比洛芬喷雾剂（Klorhex Plus®口腔喷雾剂）对接受隆鼻手术患者术后咽痛（POST）和声音嘶哑（POH）的影响。
方法 纳入2021年4月1日至2022年2月28日期间在我们诊所单独接受隆鼻手术的患者。从患者病历中记录可能影响咽痛、插管困难和手术时间的患者人口统计学数据，如年龄、性别、身高和吸烟状况。患者分为术前接受Klorhex Plus口腔喷雾剂的患者（Klorhex P组）和未接受的患者（对照组）。从患者术后手术病历中记录POST和POH。使用数字评分量表（NRS）在术后护理病历中的术后第1小时（PPL1h）、第12小时（PPL12h）和第一天（PPL1d）进行术后疼痛评估。
结果 本研究共纳入354例单独接受隆鼻手术的患者。两组在人口统计学数据方面未发现显著差异。统计学上，与对照组相比，Klorhex P组的PPL1h、PPL12h和PPL1d显著更低（所有p均<0.001）。对照组的POST和POH也显著更高（两者p均<0.001）。
结论 本研究结果表明，Klorhex Plus口腔喷雾剂是隆鼻术前预防性镇痛的有效药物。它能显著降低术后疼痛程度、POST和POH。然而，需要进一步进行全面的前瞻性研究，以便将Klorhex Plus口腔喷雾剂引入鼻科实践。
