Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.
Unit of Gynecology and Obstetrics, Department of Intensive Care, West China Second University Hospital, Sichuan University, Chengdu, China.
Minerva Anestesiol. 2020 May;86(5):546-553. doi: 10.23736/S0375-9393.20.14170-1. Epub 2020 Jan 28.
Postoperative sore throat (POST) is a common complication after tracheal intubation. Various studies have examined the efficacy of interventions using lidocaine to prevent POST. Here, we present a meta-analysis assessing their efficacy.
We systematically searched the PubMed, Embase, and Cochrane databases to identify randomized controlled trials (RCTs) assessing the efficacy of lidocaine interventions in the prevention of POST. Data synthesis was obtained by using relative risks (RRs) with 95% confidence intervals (CIs) for the incidences of POST, cough, and hoarseness after different interventions.
Twenty-seven RCTs involving 3049 patients were analyzed, including 14 on the use of intracuff lidocaine, eight on the use of a lidocaine jelly, eight on the use of a lidocaine spray, and four on the use of intravenous lidocaine. Intracuff lidocaine and intravenous lidocaine showed significant efficacy compared with controls in preventing POST at 1 h and 24 h, whereas lidocaine jelly and lidocaine spray did not. Intracuff lidocaine, lidocaine spray, and intravenous lidocaine decreased the incidence of cough, but only the intracuff lidocaine decreased the incidence of hoarseness.
This meta-analysis indicated that intracuff lidocaine and intravenous lidocaine are effective in preventing POST. In addition, intracuff lidocaine was associated with reducing the risk of both cough and hoarseness.
术后咽喉痛（POST）是气管插管后的常见并发症。许多研究已经研究了使用利多卡因预防 POST 的干预措施的疗效。在这里，我们提出了一项荟萃分析来评估其疗效。
我们系统地检索了 PubMed、Embase 和 Cochrane 数据库，以确定评估利多卡因干预措施预防 POST 疗效的随机对照试验（RCT）。通过使用相对风险（RR）和 95%置信区间（CI）来合成数据，以评估不同干预措施后 POST、咳嗽和声音嘶哑的发生率。
分析了 27 项 RCT，涉及 3049 名患者，包括 14 项关于使用气囊内利多卡因的研究、8 项关于使用利多卡因凝胶的研究、8 项关于使用利多卡因喷雾的研究和 4 项关于使用静脉内利多卡因的研究。与对照组相比，气囊内利多卡因和静脉内利多卡因在预防 1 小时和 24 小时的 POST 方面具有显著疗效，而利多卡因凝胶和利多卡因喷雾则没有。气囊内利多卡因、利多卡因喷雾和静脉内利多卡因均降低了咳嗽的发生率，但只有气囊内利多卡因降低了声音嘶哑的发生率。
这项荟萃分析表明，气囊内利多卡因和静脉内利多卡因可有效预防 POST。此外，气囊内利多卡因与降低咳嗽和声音嘶哑的风险有关。
