Kulinskiĭ V I, Ol'khovskiĭ I A, Kovalevskiĭ A N
Vopr Med Khim. 1987 May-Jun;33(3):107-12.
Administration of adenosine into mice induced a decrease in oxygen consumption (anticalorigenic effect), body temperature (hypothermal effect) and protected against acute hypoxia (antihypoxic action); all these effects are closely correlated. Isopropyl noradrenaline and theophylline prevented but propranolol and dipiridamol increased these effects of adenosine. Being administered into mice adenosine decreased both cAMP content (in skeletal muscles and kidney) and respiration in kidney homogenates. These adenosine effects appear to be realized via the following chain: A1-receptors----decrease in cellular cAMP content----inhibition of tissue oxygen consumption----development of anticalorigenic reactions----hypothermal effects----antihypoxic actions.
给小鼠注射腺苷会导致耗氧量降低（抗产热效应）、体温下降（低温效应）并预防急性缺氧（抗缺氧作用）；所有这些效应密切相关。异丙肾上腺素和茶碱可预防，但普萘洛尔和双嘧达莫会增强腺苷的这些效应。给小鼠注射腺苷会降低（骨骼肌和肾脏中的）环磷酸腺苷（cAMP）含量以及肾脏匀浆中的呼吸作用。腺苷的这些效应似乎通过以下途径实现：A1受体→细胞内cAMP含量降低→组织耗氧量抑制→抗产热反应发生→低温效应→抗缺氧作用。
