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Tc-标记干细胞在慢性肾脏病评估中的应用。

The Use of Tc-Labeled Stem Cells for Evaluation of Chronic Kidney Disease.

机构信息

Department of Radiology, School of Medicine, Laboratório de Marcação de Células e Moléculas (LMCM), Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

出版信息

Methods Mol Biol. 2023;2575:297-304. doi: 10.1007/978-1-0716-2716-7_15.

DOI:10.1007/978-1-0716-2716-7_15
PMID:36301482
Abstract

The labeling of stem cells with radionuclides allows in vivo monitoring of cell migration and homing. Here, we describe the labeling of mononuclear stem cells with 99mTc and show their biodistribution in preclinical models and patients with chronic kidney disease.

摘要

放射性核素标记干细胞可实现细胞迁移和归巢的体内监测。本研究描述了单核干细胞的 99mTc 标记，并展示了其在临床前模型和慢性肾脏病患者中的体内分布。

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本文引用的文献

1
[Chronic kidney disease and cognitive impairment].[慢性肾脏病与认知障碍]
Geriatr Psychol Neuropsychiatr Vieil. 2020 Dec 1;18(4):429-435. doi: 10.1684/pnv.2020.0897.
2
Effects of Mesenchymal Stem Cells Therapy on Cardiovascular Risk Factors in Experimental Diabetic Kidney Disease.间充质干细胞疗法对实验性糖尿病肾病心血管危险因素的影响。
Can J Kidney Health Dis. 2020 Oct 22;7:2054358120957429. doi: 10.1177/2054358120957429. eCollection 2020.
3
Regenerative Role of Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury.
干细胞衍生的细胞外囊泡在急性肾损伤中的再生作用。
Nephron. 2020;144(12):638-643. doi: 10.1159/000511347. Epub 2020 Oct 30.
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Generation of Human Induced Pluripotent Stem Cells and Differentiation into Cardiomyocytes.人诱导多能干细胞的生成和向心肌细胞的分化。
Methods Mol Biol. 2021;2158:125-139. doi: 10.1007/978-1-0716-0668-1_10.
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Safety of Allogeneic Canine Adipose Tissue-Derived Mesenchymal Stem Cell Intraspinal Transplantation in Dogs with Chronic Spinal Cord Injury.同种异体犬脂肪组织来源间充质干细胞脊髓内移植治疗犬慢性脊髓损伤的安全性
Stem Cells Int. 2017;2017:3053759. doi: 10.1155/2017/3053759. Epub 2017 May 15.
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Bone Marrow-Derived Mononuclear Cell Therapy Accelerates Renal Ischemia-Reperfusion Injury Recovery by Modulating Inflammatory, Antioxidant and Apoptotic Related Molecules.骨髓来源的单个核细胞疗法通过调节炎症、抗氧化和凋亡相关分子加速肾缺血再灌注损伤的恢复。
Cell Physiol Biochem. 2017;41(5):1736-1752. doi: 10.1159/000471866. Epub 2017 Mar 31.
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Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients.骨髓单个核细胞经动脉内或静脉内移植在亚急性脑卒中患者中的分布。
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