Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo College of Medicine and Life Sciences, Block Health Science Building, 3000 Arlington Ave, Toledo, OH, 43614-2598, USA.
Department of Pharmacology and Experimental Therapeutics, College of Pharmacy, University of Toledo, Toledo, OH, USA.
Curr Hypertens Rep. 2022 Dec;24(12):669-685. doi: 10.1007/s11906-022-01226-0. Epub 2022 Oct 27.
The study aims to capture the history and lineage of hypertension researchers from the University of Toledo in Ohio and showcase their collective scientific contributions dating from their initial discoveries of the physiology of adrenal and renal systems and genetics regulating blood pressure (BP) to its more contemporary contributions including microbiota and metabolomic links to BP regulation.
The University of Toledo College of Medicine and Life Sciences (UTCOMLS), previously known as the Medical College of Ohio, has contributed significantly to our understanding of the etiology of hypertension. Two of the scientists, Patrick Mulrow and John Rapp from UTCOMLS, have been recognized with the highest honor, the Excellence in Hypertension award from the American Heart Association for their pioneering work on the physiology and genetics of hypertension, respectively. More recently, Bina Joe has continued their legacy in the basic sciences by uncovering previously unknown novel links between microbiota and metabolites to the etiology of hypertension, work that has been recognized by the American Heart Association with multiple awards. On the clinical research front, Christopher Cooper and colleagues lead the CORAL trials and contributed importantly to the investigations on renal artery stenosis treatment paradigms. Hypertension research at this institution has not only provided these pioneering insights, but also grown careers of scientists as leaders in academia as University Presidents and Deans of Medical Schools. Through the last decade, the university has expanded its commitment to Hypertension research as evident through the development of the Center for Hypertension and Precision Medicine led by Bina Joe as its founding Director. Hypertension being the top risk factor for cardiovascular diseases, which is the leading cause of human mortality, is an important area of research in multiple international universities. The UTCOMLS is one such university which, for the last 6 decades, has made significant contributions to our current understanding of hypertension. This review is a synthesis of this rich history. Additionally, it also serves as a collection of audio archives by more recent faculty who are also prominent leaders in the field of hypertension research, including John Rapp, Bina Joe, and Christopher Cooper, which are cataloged at Interviews .
综述目的：本研究旨在追溯俄亥俄州托莱多大学的高血压研究人员的历史和渊源，并展示他们自最初发现肾上腺和肾脏系统生理学以及调节血压的遗传学以来的集体科学贡献，直至其更现代的贡献，包括微生物组和代谢组学与血压调节的联系。
最新发现：托莱多大学医学院和生命科学学院（UTCOMLS），前身为俄亥俄州立医学院，为我们对高血压病因的理解做出了重大贡献。UTCOMLS 的两位科学家 Patrick Mulrow 和 John Rapp 因其在高血压生理学和遗传学方面的开创性工作，分别获得了美国心脏协会（American Heart Association）高血压卓越奖的最高荣誉。最近，Bina Joe 继续他们的基础科学研究，揭示了微生物组和代谢物与高血压病因之间以前未知的新联系，这项工作得到了美国心脏协会的多项奖项认可。在临床研究方面，Christopher Cooper 及其同事领导了 CORAL 试验，并为肾动脉狭窄治疗模式的研究做出了重要贡献。该机构的高血压研究不仅提供了这些开创性的见解，还培养了科学家在学术界担任校长和医学院院长的领导生涯。在过去的十年中，该大学通过由 Bina Joe 作为创始主任领导的高血压和精准医学中心的发展，扩大了其对高血压研究的承诺。高血压是心血管疾病的首要风险因素，心血管疾病是人类死亡的主要原因，它是多个国际大学的重要研究领域。UTCOMLS 就是这样一所大学，在过去的 60 年里，为我们目前对高血压的理解做出了重大贡献。本综述是对这一丰富历史的综合。此外，它还收录了 John Rapp、Bina Joe 和 Christopher Cooper 等近期教职员工的音频档案，这些教职员工也是高血压研究领域的杰出领导者，这些档案都被收录在 Interviews 中。
