Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin,
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.
WMJ. 2022 Oct;121(3):E53-E56.
Acne vulgaris is the most common skin condition in late adolescence and frequently requires systemic treatment with antibiotics or androgen receptor blockers in moderateto- severe cases.
We report the case of a 17-year-old adolescent female with new onset fever, headache, and pruritic rash 1 month after she started doxycycline and spironolactone for the treatment of acne vulgaris. Later, she developed eosinophilia and transaminitis. Infectious workup was negative.
This presentation was consistent with a definite case of drug reaction with eosinophilia and systemic symptoms (DRESS). DRESS is a severe, systemic hypersensitivity drug reaction that typically occurs 2 to 8 weeks following exposure to the offending medication.
Although doxycycline and spironolactone are uncommon triggers of DRESS, they are common medications used to treat acne, and clinicians should be aware of this potential complication when counseling patients, especially adolescents.
寻常痤疮是青春期后期最常见的皮肤疾病，中重度痤疮通常需要系统使用抗生素或雄激素受体阻滞剂进行治疗。
我们报告了一例 17 岁女性青少年的病例，她在开始使用多西环素和螺内酯治疗寻常痤疮 1 个月后，出现发热、头痛和瘙痒性皮疹。随后，她出现了嗜酸性粒细胞增多和转氨酶升高。感染性检查结果为阴性。
这种表现与药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）的明确病例一致。DRESS 是一种严重的全身性过敏药物反应，通常在接触致病药物后 2 至 8 周发生。
虽然多西环素和螺内酯不太常见会引发 DRESS，但它们是常用于治疗痤疮的常见药物，临床医生在为患者，特别是青少年患者提供咨询时，应意识到这种潜在的并发症。
