Wagner U, Oppermann J, Gläser C
Z Gesamte Inn Med. 1987 May 1;42(9):233-5.
According to the at present valid definition and due to its different clinical subgroups as well as to the different therapeutic influencibility and prognosis the juvenile chronic arthritis represents a very heterogeneous feature of a disease. Systems of genetic markers increasingly obtain importance for the exact clinical specification of the juvenile chronic arthritis. The investigations described in this paper show a significant correlation of the genetically determined haptoglobin variants to the subgroups of the juvenile chronic arthritis. By means of the careful nosological differentiation which goes beyond the usual principles of subdivision the type of haptoglobin gives a diagnostic enrichment in the assessment of the juvenile chronic arthritis.
根据目前有效的定义，由于其不同的临床亚组以及不同的治疗敏感性和预后，青少年慢性关节炎代表了一种非常异质性的疾病特征。遗传标记系统对于青少年慢性关节炎的确切临床分类越来越重要。本文所述的研究表明，遗传决定的触珠蛋白变体与青少年慢性关节炎的亚组之间存在显著相关性。通过超越通常细分原则的仔细病因学区分，触珠蛋白类型在青少年慢性关节炎的评估中提供了诊断上的丰富信息。
