Samtal Chaimae, El Jaddaoui Islam, Hamdi Salsabil, Bouguenouch Laila, Ouldim Karim, Nejjari Chakib, Ghazal Hassan, Bekkari Hicham
Laboratory of Biotechnology, Environment, Agri-food and Health, Faculty of Sciences Dhar El Mahraz-Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.
Front Genet. 2022 Oct 11;13:911101. doi: 10.3389/fgene.2022.911101. eCollection 2022.
Prostate cancer (PCa) is the second most commonly diagnosed in men worldwide and one of the most frequent cancers in men in Africa. The heterogeneity of this cancer fosters the need to identify potential genetic risk factors/biomarkers. Omics variations may significantly contribute to early diagnosis and personalized treatment. However, there are few genomic studies of this disease in African populations. This review sheds light on the status of genomics research on PCa in Africa and outlines the common variants identified thus far. The allele frequencies of the most significant SNPs in Afro-native, Afro-descendants, and European populations were compared. We advocate how these few but promising data will aid in understanding, better diagnosing, and precisely treating this cancer and the need for further collaborative research on the genomics of PCa in the African continent.
前列腺癌（PCa）是全球男性中第二常见的诊断癌症，也是非洲男性中最常见的癌症之一。这种癌症的异质性促使人们需要识别潜在的遗传风险因素/生物标志物。组学变异可能对早期诊断和个性化治疗有显著贡献。然而，在非洲人群中针对这种疾病的基因组研究很少。本综述揭示了非洲前列腺癌基因组学研究的现状，并概述了迄今为止所确定的常见变异。比较了非洲原住民、非洲裔后代和欧洲人群中最显著单核苷酸多态性（SNP）的等位基因频率。我们倡导这些虽少但很有前景的数据将如何有助于理解、更好地诊断和精确治疗这种癌症，以及在非洲大陆开展前列腺癌基因组学进一步合作研究的必要性。
