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一种通过射频消融进行肺动脉环扎的新技术：在兔身上的实验研究。

A novel technique of pulmonary artery banding by means of radiofrequency ablation: An experimental study in rabbits.

作者信息

Uysal Fahrettin, Akça Tuğberk, Genç Abdüsselam, Avcı Küpeli Zehra, Özfırat Erencan, Canatan Uygur, Uysal Berfin, Şenkaya Sığnak Işık

机构信息

Department of Pediatric Cardiology, Uludağ University Faculty of Medicine, Bursa, Türkiye.

Department of Pathology, Uludağ University Faculty of Veterinary Medicine, Bursa, Türkiye.

出版信息

Turk Gogus Kalp Damar Cerrahisi Derg. 2022 Jul 29;30(3):327-333. doi: 10.5606/tgkdc.dergisi.2022.22786. eCollection 2022 Jul.

DOI:10.5606/tgkdc.dergisi.2022.22786
PMID:36303698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9580298/
Abstract

BACKGROUND

The aim of this study was to evaluate the efficacy and feasibility of a novel method of narrowing pulmonary arteries with catheter angiography using radiofrequency energy in rabbits.

METHODS

A total of nine New Zealand white rabbits weighing 3.0 to 4.2 kg each were utilized in this experimental study. After the location of pulmonary artery was confirmed by echocardiography and angiography, radiofrequency energy was applied by starting with 5 W energy for the first time and increasing by 5 W, if there was no rupture to a maximum of 20 W. Multiple applications of radiofrequency energy with different durations were performed at different levels of the pulmonary artery. Eight weeks later, surviving rabbits were sacrificed. The pulmonary arteries were removed for histological investigation.

RESULTS

Five rabbits remained alive after the experiment. There was a significant correlation between radiofrequency power and the degree of vessel thickness change in the pulmonary artery. The endothelial integrity of the tunica intima was impaired in all groups and the diameter of vessel was thickened by an average of 3.5 times.

CONCLUSION

The narrowing of the pulmonary artery using radiofrequency energy was successfully performed in a small sample size of experimental animals in this study.

摘要

背景

本研究旨在评估一种利用射频能量通过导管血管造影术使兔肺动脉狭窄的新方法的有效性和可行性。

方法

本实验研究共使用了9只体重在3.0至4.2千克之间的新西兰白兔。通过超声心动图和血管造影术确认肺动脉位置后，首次以5瓦能量施加射频能量，若无破裂则每次增加5瓦，直至最大20瓦。在肺动脉的不同水平进行不同持续时间的多次射频能量施加。8周后，处死存活的兔子。取出肺动脉进行组织学研究。

结果

实验后有5只兔子存活。射频功率与肺动脉血管厚度变化程度之间存在显著相关性。所有组的内膜内皮完整性均受损，血管直径平均增厚3.5倍。

结论

本研究在小样本实验动物中成功实现了利用射频能量使肺动脉狭窄。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/af79624e7ec8/TJTCS-2022-30-3-327-333-F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/3d1266238504/TJTCS-2022-30-3-327-333-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/c8b54836ddd1/TJTCS-2022-30-3-327-333-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/89961659f16f/TJTCS-2022-30-3-327-333-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/c5f0c52fd07b/TJTCS-2022-30-3-327-333-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/551d4d6c1d7a/TJTCS-2022-30-3-327-333-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/212f17cdeb4d/TJTCS-2022-30-3-327-333-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/af79624e7ec8/TJTCS-2022-30-3-327-333-F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/3d1266238504/TJTCS-2022-30-3-327-333-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/c8b54836ddd1/TJTCS-2022-30-3-327-333-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/89961659f16f/TJTCS-2022-30-3-327-333-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/c5f0c52fd07b/TJTCS-2022-30-3-327-333-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/551d4d6c1d7a/TJTCS-2022-30-3-327-333-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/212f17cdeb4d/TJTCS-2022-30-3-327-333-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbbf/9580298/af79624e7ec8/TJTCS-2022-30-3-327-333-F7.jpg

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本文引用的文献

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Forging ahead: Update on radiofrequency ablation technology and techniques.砥砺前行：射频消融技术与技巧的最新进展。
J Cardiovasc Electrophysiol. 2020 Jan;31(1):360-369. doi: 10.1111/jce.14317. Epub 2019 Dec 18.
2
Pulmonary artery banding in dilative cardiomyopathy of young children: review and protocol based on the current knowledge.小儿扩张型心肌病的肺动脉环扎术：基于现有知识的综述与方案
Transl Pediatr. 2019 Apr;8(2):151-160. doi: 10.21037/tp.2019.04.09.
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Radiofrequency perforation of the pulmonary valve: an efficient low cost solution.
肺动脉瓣射频穿孔：一种高效低成本的解决方案。
Acta Cardiol. 2017 Aug;72(4):419-424. doi: 10.1080/00015385.2017.1335095. Epub 2017 Jul 14.
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Results of palliation with an initial pulmonary artery band in patients with single ventricle associated with unrestricted pulmonary blood flow.单心室合并无限制肺血流患者初始肺动脉环缩术姑息治疗的结果。
J Thorac Cardiovasc Surg. 2015 Jan;149(1):213-20. doi: 10.1016/j.jtcvs.2014.08.007. Epub 2014 Aug 8.
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Bipolar ablation for deep intra-myocardial circuits: human ex vivo development and in vivo experience.用于深部心肌内环路的双极消融：人体离体研究与体内经验
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