Mauvais-Jarvis P, Lecomte P, Kuttenn F, Mowszowicz I, Mandelbaum J
Ann Endocrinol (Paris). 1978;39(3):191-9.
Twelve patients with clinic and anatomic features of polycystic ovary syndrome type 1 were investigated for gonadotropic and androgenic functions. Basal LH level was 3 times higher than in normal women in the beginning of follicular phase (16,2 +/- 3,0 mUI/ml). After LH-RH stimulation (100 microgram), peak LH level was excessively high (70 +/- 10 mUI/ml) whereas FSH was normal. Clomiphen citrate (100 mg X 5 days) was followed in all cases by temperature ascension and biologic evidence of luteinisation. Four pregnancies were obtained. Plasma androstenedione was elevated in most cases (320 +/- 30 ng/ml) with elevated urinary androstanediol (80 +/- 20 microgram/24 h.) These elevated levels were strikingly reduced in all cases after ethinyl-estradiol, 50 microgram X 20 days. Physiopathologic hypothesis consistent with these results are discussed.
对12例具有1型多囊卵巢综合征临床和解剖学特征的患者进行了促性腺激素和雄激素功能研究。在卵泡期开始时，基础促黄体生成素（LH）水平比正常女性高3倍（16.2±3.0 mUI/ml）。注射促黄体生成素释放激素（LH-RH，100微克）后，LH峰值水平过高（70±10 mUI/ml），而促卵泡生成素（FSH）正常。所有病例在服用枸橼酸氯米芬（100毫克×5天）后均出现体温上升和黄体化的生物学证据。有4例患者怀孕。大多数病例中血浆雄烯二酮升高（320±30 ng/ml），尿雄烷二醇升高（80±20微克/24小时）。在服用炔雌醇（50微克×20天）后，所有病例中这些升高的水平均显著降低。文中讨论了与这些结果相符的病理生理假说。
