癌症治疗中基于微小RNA的技术

miRNA-Based Technologies in Cancer Therapy.

作者信息

Pagoni Maria, Cava Claudia, Sideris Diamantis C, Avgeris Margaritis, Zoumpourlis Vassilios, Michalopoulos Ioannis, Drakoulis Nikolaos

机构信息

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15701 Athens, Greece.

Department of Science, Technology and Society, University School for Advanced Studies IUSS Pavia, 27100 Pavia, Italy.

出版信息

J Pers Med. 2023 Nov 9;13(11):1586. doi: 10.3390/jpm13111586.

DOI:10.3390/jpm13111586

PMID:38003902

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10672431/

Abstract

The discovery of therapeutic miRNAs is one of the most exciting challenges for pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of miRNA biology has grown considerably. Many studies have demonstrated that miRNA expression is dysregulated in many diseases, making them appealing tools for novel therapeutic approaches. This review aims to discuss miRNA biogenesis and function, as well as highlight strategies for delivering miRNA agents, presenting viral, non-viral, and exosomic delivery as therapeutic approaches for different cancer types. We also consider the therapeutic role of microRNA-mediated drug repurposing in cancer therapy.

摘要

治疗性微小RNA（miRNA）的发现是制药公司面临的最令人兴奋的挑战之一。自1993年首个miRNA被发现以来，我们对miRNA生物学的认识有了显著增长。许多研究表明，miRNA表达在多种疾病中失调，这使其成为新型治疗方法的有吸引力的工具。本综述旨在讨论miRNA的生物发生和功能，以及突出递送miRNA药物的策略，介绍病毒、非病毒和外泌体递送作为针对不同癌症类型的治疗方法。我们还考虑了微小RNA介导的药物重新利用在癌症治疗中的治疗作用。