循环miRNA-373通过靶向血管内皮生长因子（VEGF）和细胞周期蛋白D1基因对乳腺癌诊断的影响。
Impact of circulating miRNA-373 on breast cancer diagnosis through targeting VEGF and cyclin D1 genes.
作者信息
Bakr Noha M, Mahmoud Magda Sayed, Nabil Reem, Boushnak Hussein, Swellam Menha
机构信息
Biochemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, Dokki, Giza, 12622, Egypt.
High Throughput Molecular and Genetic laboratory, Center for Excellences for Advanced Sciences, National Research Centre, Dokki, Giza, 12622, Egypt.
出版信息
J Genet Eng Biotechnol. 2021 Jun 5;19(1):84. doi: 10.1186/s43141-021-00174-7.
BACKGROUND
Breast cancer (BC) is the common primary tumor among females. Hence, there is an urgent need to improve the early prediction and diagnosis of BC. For that reason, the object of the current study is to analyze the expression levels of miRNA-373 and its target genes including vascular endothelial growth factor (VEGF) and cyclin D1 in women with BC.
RESULTS
Upregulation of miRNA-373 and its target genes was observed in BC patients followed by patients with benign breast lesions compared to downregulation in controls. There was a significant association between the expression level of miRNA-373 and all clinical features. The same associations were observed between its target genes and all clinico-pathological features except hormonal status. The correlation between miRNA-373 and both genes was significant.
CONCLUSIONS
Our results prove that miRNA-373, as an oncomir, would be a vital biomarker for BC diagnosis and prognosis by targeting both VEGF and cyclin D1.
背景
乳腺癌（BC）是女性中常见的原发性肿瘤。因此，迫切需要改善BC的早期预测和诊断。出于这个原因，本研究的目的是分析miRNA-373及其靶基因（包括血管内皮生长因子（VEGF）和细胞周期蛋白D1）在BC女性中的表达水平。
结果
与对照组的下调相比，在BC患者中观察到miRNA-373及其靶基因上调，其次是乳腺良性病变患者。miRNA-373的表达水平与所有临床特征之间存在显著关联。在其靶基因与除激素状态外的所有临床病理特征之间也观察到相同的关联。miRNA-373与这两个基因之间的相关性显著。
结论
我们的结果证明，作为一种致癌miRNA，miRNA-373通过靶向VEGF和细胞周期蛋白D1，将成为BC诊断和预后的重要生物标志物。
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