Ekström Lena, Broström Susanne, Dahl Marja-Liisa, Börjesson Annica
Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.
Front Reprod Health. 2021 Dec 15;3:787954. doi: 10.3389/frph.2021.787954. eCollection 2021.
Anabolic Androgenic Steroid (AAS) abuse in the society is considered a health problem and has been associated with cardiovascular toxicity, endocrine disruption, as well as psychiatric symptoms such as aggression and cognitive dysfunction. Men and women abusing AAS, as well as persons in close relationship to AAS abusers, may encounter concerns. Subsequently, the Anti-Doping Hotline was formed 1993 to answers questions about doping in the society. Here we have reviewed 7,123 enquiries posted on the Anti-Doping Hotline website between 2005 and 2018 to see what type of questions were raised. Most questions ( = 2,924) involved AAS, 60% from abusers themselves, and 17% from a person close to an AAS abusers. Only 2.3% of the questions concerned AAS abusing women. Of the AAS specific questions most were from persons who sought personal advice regarding risks and side effects. Notably, the AAS abusers themselves were concerned about somatic side effects (e.g., gynecomastia) and problems related to the AAS injection. The persons in close relationship to an AAS abusers on the other hand, expressed concerns about psychiatric changes including mood swings and aggressivity. In addition to AAS, 26 and 13% of the questions involved dietary supplements and other doping substances, respectively. A gradual decrease of questions regarding ephedrine was noted, whereas the numbers of SARMs related questions increased during this time. Our results show that there is a continuous need to provide medical, nursing, and social support and counseling to AAS abusers and their next of kin.
社会中合成代谢雄性类固醇(AAS)滥用被视为一个健康问题,且与心血管毒性、内分泌紊乱以及诸如攻击性和认知功能障碍等精神症状有关。滥用AAS的男性和女性,以及与AAS滥用者关系密切的人,可能会遇到一些问题。随后,反兴奋剂热线于1993年成立,以解答社会中有关兴奋剂使用的问题。在此,我们回顾了2005年至2018年间发布在反兴奋剂热线网站上的7123个咨询问题,以了解提出了哪些类型的问题。大多数问题(n = 2924)涉及AAS,其中60%来自滥用者本人,17%来自与AAS滥用者关系密切的人。只有2.3%的问题涉及滥用AAS的女性。在AAS相关的问题中,大多数是寻求有关风险和副作用个人建议的人提出的。值得注意的是,AAS滥用者本人担心躯体副作用(如男性乳房发育)以及与AAS注射相关的问题。另一方面,与AAS滥用者关系密切的人则表达了对包括情绪波动和攻击性在内的精神变化的担忧。除AAS外,分别有26%和13%的问题涉及膳食补充剂和其他兴奋剂物质。麻黄碱相关问题的数量呈逐渐下降趋势,而在此期间与选择性雄激素受体调节剂(SARMs)相关问题的数量有所增加。我们的结果表明,持续需要为AAS滥用者及其近亲提供医疗、护理和社会支持与咨询。