急性重症溃疡性结肠炎伴胃肠道出血患者应用皮质类固醇后发生急性肺栓塞：一例报告
Acute pulmonary embolism following corticosteroid administration in acute severe ulcerative colitis with gastrointestinal bleeding: A case report.
作者信息
Liu Xuhan, Peng Xia, Rong Chunyan, Zhang Weihua
机构信息
Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, China.
FAW General Hospital, Changchun, China.
出版信息
Front Cardiovasc Med. 2022 Oct 11;9:1018462. doi: 10.3389/fcvm.2022.1018462. eCollection 2022.
BACKGROUND
Ulcerative colitis often leads to gastrointestinal bleeding and venous thromboembolism (VTE). At present, there is no clear conclusion about anticoagulant therapy for these patients. Treatment for ulcerative colitis usually includes 5-aminosalicylic acid, corticosteroid, and biologics. Acute ulcerative colitis, usually caused by infection, is usually severe and can be life-threatening.
CASE PRESENTATION
We report the development of VTE in a patient with severe acute ulcerative colitis who experienced gastrointestinal bleeding following hormonal therapy. The patient's indicators suggested that his blood was hypercoagulable and that his prognosis was poor.
CONCLUSION
Patients with ulcerative colitis are prone to form VTE. The use of corticosteroids during treatment increases the risk of thrombus. Anticoagulation strategy for patients with ulcerative colitis after gastrointestinal bleeding is a problem that needs to be discussed.
背景
溃疡性结肠炎常导致胃肠道出血和静脉血栓栓塞（VTE）。目前，对于这些患者的抗凝治疗尚无明确结论。溃疡性结肠炎的治疗通常包括5-氨基水杨酸、皮质类固醇和生物制剂。急性溃疡性结肠炎通常由感染引起，病情通常较重，可能危及生命。
病例报告
我们报告了1例重症急性溃疡性结肠炎患者在接受激素治疗后发生胃肠道出血并出现VTE的情况。患者的指标提示其血液呈高凝状态，预后较差。
结论
溃疡性结肠炎患者易于形成VTE。治疗期间使用皮质类固醇会增加血栓形成风险。溃疡性结肠炎患者在胃肠道出血后的抗凝策略是一个需要探讨的问题。
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