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由2型单纯疱疹病毒引起的复发性良性淋巴细胞性(莫拉雷氏)脑膜炎

Recurrent benign lymphocytic (Mollaret's) meningitis due to herpes simplex virus type 2.

作者信息

Grinney Michael, Mohseni Michael M

机构信息

Department of Emergency Medicine, Mayo Clinic, Jacksonville, Florida.

出版信息

Proc (Bayl Univ Med Cent). 2022 Aug 11;35(6):820-821. doi: 10.1080/08998280.2022.2108991. eCollection 2022.

Abstract

We present a rare case of Mollaret's meningitis in a young patient with seven prior episodes of recurrent meningitis. The patient presented with headache, fever, neck stiffness, nausea, and vomiting. Brain imaging revealed no acute abnormalities. Lumbar puncture revealed elevated nucleated cells with lymphocytic predominance. The patient was started on antimicrobials including acyclovir. Cerebrospinal fluid polymerase chain reaction was positive for herpes simplex virus type 2. Her 2-day hospital course was uncomplicated, and she was discharged in good condition. Mollaret's meningitis, also known as recurrent benign lymphocytic meningitis, is a rare clinical disorder characterized by at least three recurrent episodes of meningitis associated with spontaneous recovery with or without antiviral therapy. Herpes simplex virus type 2 has frequently been implicated in the setting of this illness.

摘要

我们报告一例年轻患者的莫拉雷脑膜炎罕见病例,该患者既往有七次复发性脑膜炎发作史。患者表现为头痛、发热、颈部僵硬、恶心和呕吐。脑部影像学检查未发现急性异常。腰椎穿刺显示有核细胞增多,以淋巴细胞为主。患者开始接受包括阿昔洛韦在内的抗菌药物治疗。脑脊液聚合酶链反应检测显示2型单纯疱疹病毒呈阳性。她为期2天的住院过程无并发症,出院时情况良好。莫拉雷脑膜炎,也称为复发性良性淋巴细胞性脑膜炎,是一种罕见的临床疾病,其特征是至少三次复发性脑膜炎发作,无论是否进行抗病毒治疗均可自发恢复。2型单纯疱疹病毒常与这种疾病有关。

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