Key Laboratory of Addiction Research of Zhejiang Province, Ningbo Kangning Hospital, Ningbo, China.
School of Medicine, Ningbo University, Ningbo, China.
J Clin Lab Anal. 2022 Nov;36(11):e24750. doi: 10.1002/jcla.24750. Epub 2022 Oct 28.
Genetic variations can affect individual response to methadone maintenance treatment (MMT) for heroin addiction. The A118G variant (rs1799971) in the mu opioid receptor gene (OPRM1) is a potential candidate single nucleotide polymorphism (SNP) for personalized MMT. This study determined whether rs1799971 is related to MMT response or dose.
We recruited 286 MMT patients from a Han Chinese population. The rs1799971 genotype was determined via TaqMan genotyping assay. The genetic effect of this SNP on MMT response or dose was evaluated using logistic regression. A meta-analysis was performed to merge all available data to evaluate the role of rs1799971 in MMT using RevMan 5.3 software.
No statistical significance was observed in the association between the OPRM1 rs1799971 and MMT response or dose in our Chinese cohort. Meta-analysis indicated that the OPRM1 A118G variation was not significantly associated with MMT response or dose requirement.
The results suggest that rs1799971 in OPRM1 might not play a critical role alone in influencing MMT response or dose.
遗传变异可能会影响个体对海洛因成瘾者美沙酮维持治疗（MMT）的反应。μ阿片受体基因（OPRM1）中的 A118G 变异（rs1799971）是个性化 MMT 的潜在候选单核苷酸多态性（SNP）。本研究旨在确定 rs1799971 是否与 MMT 反应或剂量有关。
我们从汉族人群中招募了 286 名 MMT 患者。通过 TaqMan 基因分型检测确定 rs1799971 基因型。使用逻辑回归评估该 SNP 对 MMT 反应或剂量的遗传效应。采用 RevMan 5.3 软件进行荟萃分析，合并所有可用数据来评估 rs1799971 在 MMT 中的作用。
在中国队列中，OPRM1 rs1799971 与 MMT 反应或剂量之间无显著相关性。荟萃分析表明，OPRM1 A118G 变异与 MMT 反应或剂量需求无显著相关性。
结果表明，OPRM1 中的 rs1799971 单独可能不会在影响 MMT 反应或剂量方面发挥关键作用。
