Correlation between gene polymorphisms and perioperative analgesia in patients undergoing gynecological surgery.

OBJECTIVES

This study aims to identify specific single nucleotide polymorphism (SNP) correlated to perioperative analgesia in patients undergoing laparoscopic gynecological surgery.

METHODS

A total of 200 females meeting specific criteria underwent gynecological laparoscopic procedures under general anesthesia. Preoperative pain sensitivity was evaluated using Pain Sensitivity Questionnaire and Pain Catastrophizing Scale (PCS). Venous blood samples were collected for SNP analysis of nine genes. The study analyzed the correlation between SNPs and pre-operative pain assessment, analgesics usage, and the occurrence of related adverse effects.

RESULTS

Six out of nine identified loci showed polymorphisms. The PCS scores were higher in the mutation group (GG + GC) for compared to the CC group (P < 0.05). No differences were observed in visual analog scale or Ramsay sedation scores between the mutation and wild-type groups for any of the SNPs (P < 0.05). Patients in the mutant group (AG + GG) for had higher analgesic usage within 24 h compared to the wild-type group (P < 0.05). The consumption of intraoperative remifentanil was higher in the mutation group (GG + GC) of than in the CC group. The Multifactorial Dimensionality Reduction analysis suggests that the optimal interaction model includes and * together.

CONCLUSION

Patients with GG and AG genotypes of gene required more 24-h postoperative analgesics after gynecological surgery compared to those with AA genotype. A SNP-SNP interaction was observed between and . (www.chictr.org.cn, registration number: ChiCTR2200062425).