Landa A I, Donoso A O
Acta Endocrinol (Copenh). 1987 Aug;115(4):490-6. doi: 10.1530/acta.0.1150490.
The effects of gamma-aminobutyric acid (GABA) increase at the nucleus locus coeruleus (LC) on pro-oestrus LH release and ovulation were evaluated in rats. Local microinjection of the GABA-transaminase inhibitor gamma-vinyl-GABA (GVG) produced 6 h later a marked increase in GABA in the LC. Such action caused a significant decrease of plasma LH levels and prevented the pro-oestrus LH surge. In some animals, plasma prolactin levels were also lowered, but in others its plasma concentrations were high and similar to that in controls. Ovulation did not occur in the rats treated with GVG. In additional experiments, the periventricular gray substance (PGS) close to the locus coeruleus was injected with GVG. Results obtained show a LH surge blockade and failure of ovulation in most of these rats. These findings may be interpreted on the basis of GABA action on rostral LC cells that project to the PGS. The results altogether suggest that through neurons of the locus coeruleus, GABA may exert an inhibitory role in the regulation of LH secretion.
在大鼠中评估了蓝斑核（LC）处γ-氨基丁酸（GABA）增加对动情前期促黄体生成素（LH）释放和排卵的影响。局部微量注射GABA转氨酶抑制剂γ-乙烯基-GABA（GVG）6小时后，LC中的GABA显著增加。这种作用导致血浆LH水平显著降低，并阻止了动情前期LH峰的出现。在一些动物中，血浆催乳素水平也降低了，但在另一些动物中，其血浆浓度很高且与对照组相似。用GVG处理的大鼠未发生排卵。在额外的实验中，向靠近蓝斑核的室周灰质（PGS）注射GVG。所获得的结果表明，这些大鼠中的大多数出现了LH峰阻断和排卵失败。这些发现可以基于GABA对投射到PGS的嘴侧LC细胞的作用来解释。这些结果共同表明，通过蓝斑核的神经元，GABA可能在LH分泌的调节中发挥抑制作用。
