Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, Texas.
College of Health Solutions, Arizona State University, Phoenix.
Int J Yoga Therap. 2022 Jan 1;32(2022). doi: 10.17761/2022-D-21-00047.
Bone marrow transplant (BMT) is a curative procedure for patients with hematological malignancies, hemoglobinopathies, and errors of inborn metabolism. Survivors are not without symptom burden. The purpose of this study was to assess the feasibility of a 12-week online yoga intervention compared to an educational control group in survivors of allogenic BMT. Participants were recruited nationally. Consenting participants were assigned to online yoga or a podcast control. Yoga and control group participants were instructed to complete 12 weeks of 60 minutes/week of online yoga and podcasts, respectively. Study participants were asked to complete online questionnaires at baseline (wk 0), midpoint (wk 6), postintervention (wk 12), and follow-up (wk 20). Feasibility benchmarks included > 70% satisfied with intervention and > 70% intending to continue participating in online yoga (acceptability); > 70% of participants achieving > 42 minutes/week of online yoga (demand); > 70% completing all four questionnaires (practicality); and at least small effect sizes of the intervention on Lee Symptom Score, physical function, fatigue, anxiety, sleep disturbance, social functioning, pain interference, depression, and quality of life as compared to control group (limited efficacy). Seventy-two participants consented and enrolled in the study (yoga group n = 33; podcast group n = 39). Of the yoga group participants, 54.5% (n = 19) completed the postintervention questionnaire, with 73.7% (n = 14) indicating they were satisfied/very satisfied and 15.8% (n = 3) likely/very likely to continue online yoga. Yoga participation averaged 31.98 minutes/week across 12 weeks. Both groups experienced a significant improvement in the Lee Symptom Score (6.2%-8.7% improvement from baseline) and depressive symptoms (5.3%-6.6% improvement from baseline). The yoga group experienced a significant reduction in pain (6.1% from baseline), and the podcast group experienced a significant reduction in fatigue (6.4% improvement from baseline). Online yoga was not found to be feasible to deliver to this population of survivors of BMT. However, there was satisfaction with online yoga among the majority of survivors of BMT, and beneficial effects were experienced in the yoga group on Lee Symptom Score, depressive symptoms, and pain. Future research is needed to enhance our understanding of barriers to online yoga participation for survivors of BMT and to determine its efficacy.
骨髓移植（BMT）是治疗血液系统恶性肿瘤、血红蛋白病和先天性代谢错误患者的一种有治愈可能的方法。幸存者并非没有症状负担。本研究的目的是评估与教育对照组相比，为期 12 周的在线瑜伽干预在同种异体 BMT 幸存者中的可行性。参与者是在全国范围内招募的。同意参与的参与者被分配到在线瑜伽或播客对照组。瑜伽和对照组的参与者被要求分别完成 12 周、每周 60 分钟的在线瑜伽和播客。研究参与者在基线（第 0 周）、中点（第 6 周）、干预后（第 12 周）和随访（第 20 周）时完成在线问卷。可行性基准包括>70%的参与者对干预措施感到满意和>70%的参与者打算继续参加在线瑜伽（可接受性）；>70%的参与者每周完成>42 分钟的在线瑜伽（需求）；>70%的参与者完成所有四份问卷（实用性）；以及与对照组相比，干预措施对 Lee 症状评分、身体功能、疲劳、焦虑、睡眠障碍、社会功能、疼痛干扰、抑郁和生活质量至少有小的影响（有限的疗效）。72 名参与者同意并参与了这项研究（瑜伽组 n=33；播客组 n=39）。瑜伽组的 54.5%（n=19）完成了干预后的问卷，其中 73.7%（n=14）表示满意/非常满意，15.8%（n=3）表示可能/非常可能继续在线瑜伽。瑜伽组每周平均参与 31.98 分钟，共 12 周。两组的 Lee 症状评分均有显著改善（基线时改善 6.2%-8.7%），抑郁症状也有显著改善（基线时改善 5.3%-6.6%）。瑜伽组的疼痛显著减轻（从基线时减轻 6.1%），播客组的疲劳显著减轻（从基线时减轻 6.4%）。没有发现向 BMT 幸存者群体提供在线瑜伽是可行的。然而，大多数 BMT 幸存者对在线瑜伽感到满意，瑜伽组在 Lee 症状评分、抑郁症状和疼痛方面也有受益。需要进一步的研究来增强我们对 BMT 幸存者在线瑜伽参与障碍的理解，并确定其疗效。
