孕期、分娩期及产褥期的血清苯妥英水平。
Serum phenytoin during pregnancy, labor and puerperium.
作者信息
Bardy A H, Hiilesmaa V K, Teramo K A
出版信息
Acta Neurol Scand. 1987 Jun;75(6):374-5. doi: 10.1111/j.1600-0404.1987.tb05464.x.
Abstract
111 pregnancies of epileptic women on phenytoin therapy were observed in a prospective study. Maternal serum phenytoin concentrations were measured monthly or bi-weekly during pregnancy, labor and puerperium. The concentration decreased towards the end of pregnancy and was lowest at delivery. In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency.
摘要
在一项前瞻性研究中，观察了111例接受苯妥英治疗的癫痫女性的妊娠情况。在妊娠、分娩和产褥期，每月或每两周测量一次孕妇血清苯妥英浓度。浓度在妊娠末期下降，在分娩时最低。48%的患者必须增加药物剂量以应对癫痫发作频率的增加。
Zotero 插件