小胶质细胞是 Aβ 和细胞碎片的 SYK。
Microglia are SYK of Aβ and cell debris.
机构信息
Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Department of Neurobiology, Brudnik Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA; University of Massachusetts Chan Morningside Graduate School of Biomedical Sciences, Neuroscience Program, Worcester, MA, USA.
出版信息
Cell. 2022 Oct 27;185(22):4043-4045. doi: 10.1016/j.cell.2022.09.043.
During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo.
在神经退行性疾病中，被称为“小胶质细胞”的中枢神经系统常驻巨噬细胞发挥神经保护作用，吞噬有毒的蛋白质聚集体和细胞碎片。在本期《细胞》杂志中，两组研究人员独立展示了脾酪氨酸激酶 (SYK) 如何作为小胶质细胞表面受体的下游分子，在体内促进这种神经保护程序。
Zotero 插件