Clinical Data Center, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Radiology Department, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
BMJ Open. 2022 Oct 28;12(10):e064967. doi: 10.1136/bmjopen-2022-064967.
This study aimed to investigate the seasonality of paediatric intussusception and the associations between meteorological factors and paediatric intussusception in Hangzhou, as well as aimed to compare the variance in sex and disease type.
An 8-year retrospective study was conducted from January 2014 to December 2021 in the Children's Hospital of Zhejiang University, Hangzhou, China.
This was a single-centre retrospective study review of intussusception cases in a large Children's Hospital in Hangzhou.
There were 17 674 patients with intussusception in this study.
A Spearman correlation analysis and Poisson regression analysis were used to determine the association between weekly intussusception cases and meteorological factors. The seasonality of paediatric intussusception was demonstrated via the t-test and visualised.
In January, May and December, there were relatively more intussusception patients. In February, there was a trough in the number of intussusception patients. Both the Spearman correlation analysis and Poisson regression analysis proved that weekly intussusception cases had significant associations with temperature (λ=-0.205, p<0.01; β=-0.080, p<0.01), feels-like temperature (λ=-0.214, p<0.01; β=-0.012, p<0.01), dew (λ=-0.249, p<0.01; β=0.095, p<0.01), humidity (λ=-0.230, p<0.01; β=-0.037, p<0.01), precipitation (λ=-0.148, p<0.01; β=-0.001, p<0.01), windspeed (λ=-0.135, p<0.01; β=0.005, p<0.01), visibility (λ=-0.206, p<0.01; β=-0.066, p<0.01), sea level pressure (λ=0.171, p<0.01; β=-0.004, p<0.01) and a total of 20 of 25 dynamic meteorological factors (p<0.05). These associations reflected gender differences but showed stronger associations in groups that were prone to recurrence.
Paediatric intussusception in Hangzhou showed a seasonal tendency. Additionally, intussusception was significantly associated with certain meteorological factors in all of the cases. These findings suggest that parents and paediatricians should be more vigilant about the occurrence of intussusception in children regarding seasonal change times and climate change times.
本研究旨在探讨小儿肠套叠的季节性，并分析气象因素与杭州小儿肠套叠之间的关系，同时比较不同性别和疾病类型的差异。
这是一项 2014 年 1 月至 2021 年 12 月在中国浙江大学儿童医院进行的 8 年回顾性研究。
本研究为杭州市一家大型儿童医院的单中心回顾性研究。
本研究共纳入 17674 例肠套叠患儿。
采用 Spearman 相关分析和 Poisson 回归分析确定每周肠套叠病例与气象因素之间的关系。采用 t 检验和可视化方法展示小儿肠套叠的季节性。
1 月、5 月和 12 月肠套叠患儿相对较多，2 月肠套叠患儿较少。Spearman 相关分析和 Poisson 回归分析均表明，每周肠套叠病例与温度（λ=-0.205，p<0.01；β=-0.080，p<0.01）、体感温度（λ=-0.214，p<0.01；β=-0.012，p<0.01）、露（λ=-0.249，p<0.01；β=0.095，p<0.01）、湿度（λ=-0.230，p<0.01；β=-0.037，p<0.01）、降水量（λ=-0.148，p<0.01；β=-0.001，p<0.01）、风速（λ=-0.135，p<0.01；β=0.005，p<0.01）、能见度（λ=-0.206，p<0.01；β=-0.066，p<0.01）、海平面气压（λ=0.171，p<0.01；β=-0.004，p<0.01）等 25 个动态气象因素存在显著相关性（p<0.05）。这些相关性反映了性别差异，但在易复发组中相关性更强。
杭州小儿肠套叠具有季节性趋势，且肠套叠与气象因素之间存在显著相关性，无论整体情况还是不同性别和疾病类型。这些发现提示家长和儿科医生应更加关注季节变化和气候变化时期儿童肠套叠的发生。
