Eriksson S, Simon-Oppermann C, Simon E, Gray D A
Acta Physiol Scand. 1987 Aug;130(4):575-83. doi: 10.1111/j.1748-1716.1987.tb08179.x.
Arginine vasopressin (AVP) is assumed to be involved as a central transmitter or modulator in the control of autonomic functions including thirst. In conscious dogs AVP concentration in cerebrospinal fluid (CSF) from the anterior part of the third ventricle (A3V) was analysed before and after local elevation of CSF osmolality by intracerebroventricular (i.c.v.) infusion of 0.35 M NaCl and after i.c.v. AVP infusion at 46 and 138 fmol ml-1 for 10 min. In addition, the effects of these i.c.v. infusions on water intake, plasma AVP concentration and blood pressure were investigated. In euhydrated dogs 0.35 M NaCl i.c.v. did not alter AVP concentration in the CSF during the subsequent 2 h. In contrast, plasma AVP concentration had increased significantly from 3.4 +/- 0.3 (control) to 6.4 +/- 0.7 and 4.7 +/- 0.3 fmol ml-1, 4 and 16 min, respectively, after the hypertonic stimulus. Drinking was stimulated with an average water intake of 14.5 +/- 3.7 ml kg-1 body wt. However, AVP infusion into the A3V did not elicit water intake despite increases of AVP concentration in the A3V by factors up to 40 above control. The same animals responded with spontaneous drinking to 0.35 M NaCl i.c.v. administered 160 min after the end of AVP infusions. Exogenously administered AVP disappeared from the A3V with a time constant of 13.8 min. The results do not support the view that AVP in the A3V CSF per se stimulates drinking.
精氨酸加压素（AVP）被认为作为一种中枢递质或调节剂参与包括口渴在内的自主功能控制。在清醒犬中，通过脑室内（i.c.v.）注入0.35 M NaCl使第三脑室前部（A3V）的脑脊液（CSF）渗透压局部升高前后，以及在分别以46和138 fmol/ml的剂量i.c.v.注入AVP 10分钟后，对A3V的CSF中AVP浓度进行了分析。此外，还研究了这些i.c.v.注入对水摄入、血浆AVP浓度和血压的影响。在水合正常的犬中，i.c.v.注入0.35 M NaCl在随后2小时内未改变CSF中的AVP浓度。相反，在高渗刺激后4分钟和16分钟，血浆AVP浓度分别从对照值3.4±0.3显著升高至6.4±0.7和4.7±0.3 fmol/ml。饮水受到刺激，平均水摄入量为14.5±3.7 ml/kg体重。然而，尽管A3V中AVP浓度比对照值增加了高达40倍，但向A3V注入AVP并未引发饮水。在AVP注入结束160分钟后，向同一批动物i.c.v.注入0.35 M NaCl，动物出现自发饮水。外源性注入的AVP以13.8分钟的时间常数从A3V中消失。这些结果不支持A3V CSF中的AVP本身刺激饮水这一观点。
