Sjöström A, Conradi N G, Andersson S A
Acta Physiol Scand. 1987 Aug;130(4):705-11. doi: 10.1111/j.1748-1716.1987.tb08195.x.
Recent studies on the specific visual system have indicated that early induced protein deprivation results in an impaired transmission from cell to cell in the cortex. To further investigate cortical mechanisms the response to repetitive light flashes and to electrical stimulation of the optic tract (OT) and the dorsal lateral geniculate nucleus (dLGN) were examined. The first potential of the surface visual evoked response (VER) and the monosynaptic response to OT and dLGN stimulation showed similar sensitivity to repetitive stimulation in C and PD rats. In PD rats later activity was significantly more sensitive to repetitive stimulation than in controls. By using paired stimuli with a short inter-stimulus interval, similar inhibitory mechanisms in PD and C rats were demonstrated. The results support the view that protein deprivation results in impaired cortical synaptic activation. The results are discussed in relation to previously described impairment at the cortical level in malnourished animals.
近期对特定视觉系统的研究表明，早期诱导的蛋白质缺乏会导致皮质中细胞间的信号传递受损。为了进一步研究皮质机制，研究人员检测了对重复闪光以及对视束（OT）和背外侧膝状核（dLGN）进行电刺激的反应。在正常大鼠（C）和蛋白质缺乏大鼠（PD）中，表面视觉诱发电位（VER）的首个电位以及对OT和dLGN刺激的单突触反应对重复刺激表现出相似的敏感性。在PD大鼠中，后续活动对重复刺激的敏感性明显高于对照组。通过使用短刺激间隔的成对刺激，在PD大鼠和C大鼠中证明了类似的抑制机制。这些结果支持了蛋白质缺乏会导致皮质突触激活受损的观点。本文将结合先前描述的营养不良动物皮质水平的损伤来讨论这些结果。
