Sjöström A, Conradi N G, Gustafsson B, Wigström H
Acta Physiol Scand. 1985 Nov;125(3):353-8. doi: 10.1111/j.1748-1716.1985.tb07729.x.
A persistent increase in the latencies of the visual evoked response recorded from the cortical surface of protein deprived adult rats was described recently (Sjöström et al. 1984). The morphological correlate to this alteration is unknown. Previous studies on malnourished rats have shown a reduction of axonal diameters and in the number of myelin lamellae in relation to axonal circumference, and hence the possibility of a decrease in fibre conduction velocity must be considered. In parallel study, we have established that changes in diameters and myelination of optic nerve fibres similar to those previously reported in malnourished rats are present in adult protein deprived (PD) rats (Conradi et al. 1985). In the present paper, recordings of optic nerves in vitro from adult normal (C) and protein deprived (PD) rats are described. The compound action potentials were very similar in the two groups. Three positive peaks were easily defined, probably corresponding to three functional groups of optic nerve fibers. No significant differences in amplitudes or conduction velocities for the three peaks were found between the C and PD rats. It is concluded that the increased latencies of the evoked response are not caused by a decrease in conduction velocity.
最近有报道称，从蛋白质缺乏的成年大鼠皮质表面记录到的视觉诱发电位潜伏期持续增加（Sjöström等人，1984年）。这种改变的形态学相关因素尚不清楚。先前对营养不良大鼠的研究表明，轴突直径以及与轴突周长相关的髓鞘层数减少，因此必须考虑纤维传导速度降低的可能性。在一项平行研究中，我们已经确定，成年蛋白质缺乏（PD）大鼠的视神经纤维直径和髓鞘形成的变化与先前在营养不良大鼠中报道的相似（Conradi等人，1985年）。在本文中，描述了从成年正常（C）和蛋白质缺乏（PD）大鼠体外记录的视神经情况。两组的复合动作电位非常相似。很容易确定三个正向峰，可能对应于视神经纤维的三个功能组。在C组和PD组大鼠之间，这三个峰的振幅或传导速度没有发现显著差异。结论是，诱发电位潜伏期的增加不是由传导速度降低引起的。
