Department of Clinical Sciences, Rheumatology, Lund University, Lund, Sweden.
Spenshult research and development centre, Halmstad, Sweden.
BMC Musculoskelet Disord. 2022 Oct 28;23(1):938. doi: 10.1186/s12891-022-05881-x.
Metabolic factors have been shown to be associated to severe radiographic knee osteoarthritis (RKOA). However, more knowledge is needed in early clinical knee osteoarthritis (KOA). The aim was to study associations between metabolic factors and radiographic knee osteoarthritis (OA) in individuals with knee pain. A second aim was to study associations between metabolic factors and RKOA in those with normal BMI and in those overweight/obese, respectively.
This cross-sectional study included 282 individuals with knee pain (without cruciate ligament injury) and aged 30-67 years, and 70% women. Waist circumference, body mass index (BMI), proportion of fat and visceral fat area (VFA) were assessed. RKOA was defined as Ahlbäck grade 1 in at least one knee. Fasting blood samples were taken and triglycerides, cholesterol (total, low density lipoprotein (LDL) and high density lipoprotein (HDL)), C-reactive protein (CRP), glucose, HbA1C were analysed. Metabolic syndrome was defined in accordance with the International Diabetes Federation (IDF). Associations were analysed by logistic regression.
Individuals with RKOA were older, had higher BMI, higher VFA, larger waist circumference and had increased total cholesterol, triglycerides and LDL-cholesterol, but not fasting glucose. There was no difference between the group with RKOA vs. non-radiographic group regarding the presence of metabolic syndrome. In a subgroup analysis of individuals with normal BMI (n = 126), those with RKOA had higher VFA, more central obesity, higher levels of CRP and total cholesterol, compared with individuals without RKOA. In individuals with obesity, age was the only outcome associated to RKOA.
There were clear associations between metabolic factors and RKOA in individuals with knee pain, also in those with normal BMI. In individuals with obesity age was the only variable associated to RKOA.
clinicalTrials.gov Identifier: NCT04928170.
代谢因素已被证明与严重的放射学膝关节骨关节炎（RKOA）有关。然而，在早期临床膝关节骨关节炎（KOA）中需要更多的知识。目的是研究代谢因素与膝关节疼痛患者的放射学膝关节骨关节炎（OA）之间的关系。第二个目的是分别研究代谢因素与正常 BMI 人群和超重/肥胖人群中 RKOA 的关系。
这项横断面研究包括 282 名膝关节疼痛（无十字韧带损伤）且年龄在 30-67 岁之间的患者，其中 70%为女性。评估了腰围、体重指数（BMI）、体脂比例和内脏脂肪面积（VFA）。RKOA 定义为至少一侧膝关节 Ahlbäck 分级 1。抽取空腹血样，分析甘油三酯、胆固醇（总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL））、C 反应蛋白（CRP）、血糖、HbA1C。代谢综合征按照国际糖尿病联合会（IDF）的标准定义。通过逻辑回归分析关联。
患有 RKOA 的患者年龄较大，BMI 较高，VFA 较大，腰围较大，总胆固醇、甘油三酯和 LDL 胆固醇水平较高，但空腹血糖水平没有差异。患有 RKOA 的患者与无放射学组相比，代谢综合征的发生率没有差异。在 BMI 正常（n=126）的患者亚组分析中，与无 RKOA 的患者相比，患有 RKOA 的患者 VFA 较高，中心性肥胖较多，CRP 和总胆固醇水平较高。在肥胖患者中，年龄是唯一与 RKOA 相关的变量。
膝关节疼痛患者，甚至 BMI 正常的患者，代谢因素与 RKOA 之间存在明显关联。在肥胖患者中，年龄是唯一与 RKOA 相关的变量。
clinicalTrials.gov 标识符：NCT04928170。
