Donauer E, Drumm G, Moringlane J, Ostertag C, Kivelitz R
Acta Neurochir (Wien). 1987;86(3-4):83-8. doi: 10.1007/BF01402289.
In ventriculitis caused by Gentamicin-resistant staphylococcus aureus and staphylococcus epidermidis, Netilmicin was administered intrathecally to 19 patients under continuous control of the Netilmicin concentration in cerebro-spinal fluid (CSF). This therapy was able to bring these otherwise lethal infections under control, usually within 10 days. Pharmacokinetic studies with different doses have shown that doses of 2 X 3 mg are to be recommended in moderately severe cases of ventriculitis, and in most severe infections 3 X 3 mg daily intraventricularly for adults. In infants daily intraventricular injections of 2 X 0.4-0.5 mg Netilmicin are a sufficient dose to produce an effective antibiotic concentration level.
在由耐庆大霉素的金黄色葡萄球菌和表皮葡萄球菌引起的脑室炎中，对19例患者在脑脊液（CSF）中奈替米星浓度的持续监测下进行鞘内注射奈替米星治疗。这种治疗方法通常能够在10天内控制这些原本致命的感染。不同剂量的药代动力学研究表明，在中度严重的脑室炎病例中，推荐使用2×3mg的剂量，对于最严重的感染，成人每天脑室内注射3×3mg。对于婴儿，每天脑室内注射2×0.4 - 0.5mg奈替米星足以产生有效的抗生素浓度水平。
