Gombert M E, Landesman S H, Corrado M L, Stein S C, Melvin E T, Cummings M
J Neurosurg. 1981 Oct;55(4):633-6. doi: 10.3171/jns.1981.55.4.0633.
Three patients with Staphylococcus epidermis meningitis associated with cerebrospinal fluid (CSF) shunt devices were treated with a combination of intravenous vancomycin and oral rifampin. Two of the isolates were methicillin-resistant. All patients had a favorable clinical response. Time-kill curves showed that the addition of rifampin to vancomycin resulted in enhanced bactericidal activity against all isolates when compared to either antibiotic alone. This finding suggests that the combination of oral rifampin and intravenous vancomycin may be useful in the treatment of methicillin-resistant and recalcitrant methicillin-sensitive S. epidermis meningitis associated with CSF shunts. In vitro susceptibility testing should be performed.
三名患有与脑脊液（CSF）分流装置相关的表皮葡萄球菌脑膜炎的患者接受了静脉注射万古霉素和口服利福平的联合治疗。分离出的菌株中有两株对甲氧西林耐药。所有患者临床反应良好。时间杀菌曲线显示，与单独使用任何一种抗生素相比，万古霉素中加入利福平可增强对所有分离菌株的杀菌活性。这一发现表明，口服利福平与静脉注射万古霉素联合使用可能有助于治疗与脑脊液分流相关的耐甲氧西林和顽固性甲氧西林敏感表皮葡萄球菌脑膜炎。应进行体外药敏试验。
