Tran Tiffany M, Rao Dinesh S
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Molecular, Cellular, and Integrative Physiology Interdepartmental Ph.D. Program, UCLA, Los Angeles, CA, 90095, USA.
Exp Hematol Oncol. 2022 Oct 28;11(1):80. doi: 10.1186/s40164-022-00343-5.
RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease. RBPs influence the fate of mRNAs through multiple mechanisms of action such as RNA modifications, alternative splicing, and miR-mediated regulation. This complex and, often, combinatorial regulation by RBPs critically impacts the expression of oncogenic transcripts and, thus, the activation of pathways that drive oncogenesis. Here, we focus on the major features of RBPs, their mechanisms of action, and discuss the current progress in investigating the function of important RBPs in MLL-rearranged leukemia.
RNA结合蛋白（RBPs）最近已成为正常发育和疾病中重要的转录后基因表达调节因子。RBPs通过多种作用机制影响mRNA的命运，如RNA修饰、可变剪接和miR介导的调节。RBPs这种复杂且通常是组合式的调节对致癌转录本的表达产生关键影响，进而影响驱动肿瘤发生的信号通路的激活。在此，我们聚焦于RBPs的主要特征、它们的作用机制，并讨论在研究重要RBPs在MLL重排白血病中的功能方面的当前进展。
