Rosario Karen Flores, Brezitski Kyla, Arps Kelly, Milne Megan, Doss Jayanth, Karra Ravi
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USA.
Curr Allergy Asthma Rep. 2022 Dec;22(12):171-182. doi: 10.1007/s11882-022-01046-x. Epub 2022 Oct 29.
Cardiac sarcoidosis (CS) is an important cause of non-ischemic cardiomyopathy and has specific diagnostic and therapeutic considerations. With advances in imaging techniques and treatment approaches, the approach to monitoring disease progression and management of CS continues to evolve. The purpose of this review is to highlight advances in CS diagnosis and treatment and present a center's multidisciplinary approach to CS care.
In this review, we highlight advances in granuloma biology along with contemporary diagnostic approaches. Moreover, we expand on current targets of immunosuppression focused on granuloma biology and concurrent advances in the cardiovascular care of CS in light of recent guideline recommendations. Here, we review advances in the understanding of the sarcoidosis granuloma along with contemporary diagnostic and therapeutic considerations for CS. Additionally, we highlight knowledge gaps and areas for future research in CS treatment.
心脏结节病(CS)是非缺血性心肌病的重要病因,有特定的诊断和治疗考量。随着成像技术和治疗方法的进步,监测CS疾病进展和管理的方法不断演变。本综述的目的是强调CS诊断和治疗方面的进展,并介绍一个中心对CS护理的多学科方法。
在本综述中,我们强调了肉芽肿生物学的进展以及当代诊断方法。此外,根据最近的指南建议,我们阐述了目前针对肉芽肿生物学的免疫抑制靶点以及CS心血管护理方面的同步进展。在此,我们回顾了对结节病肉芽肿认识的进展以及CS的当代诊断和治疗考量。此外,我们强调了CS治疗方面的知识空白和未来研究领域。