Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany.
Pathol Res Pract. 2022 Dec;240:154178. doi: 10.1016/j.prp.2022.154178. Epub 2022 Oct 20.
Biopsies from patients with ulcerative colitis (UC) often show crypt branching´s (CB).
The purpose was to analyze the frequency of CB in biopsies with dysplasia in UC (D-UC).
Digitalized-sections from 49 consecutive D-UC cases were reviewed and all CB were recorded. Potential confounders such as gender, age, UC-duration, localization in the colorectum, degree of epithelial dysplasia and number of mucosal samples/biopsy, were investigated.
A total of 334 dysplastic CB (DCB) were recorded in the 49 D-UC cases; 321 (96.1%) DCB were in asymmetric branching (DCAB), and the remaining 13 (3.9%), in symmetric branching (DCSB). Out of the 49 D-UC cases, 41% had 1-4 DCAB, 43% 5-9 DCAB, 10% 10-15 DCAB, and the remaining 6%, ≥ 16 DCAB. Low-grade dysplasia (LGD) was present in 44 (90%) of the 49 D-UC cases, and high-grade dysplasia (HGD) in the remaining 5 (10%). The frequency of DCAB was not influenced by age, gender, biopsy site (right colon, left colon, or rectum), number of mucosal samples/biopsy, degree of dysplasia or UC duration.
Two novel histologic phenotypes of DCB in UC-associated dysplasia are reported, namely DCAB and DCSB. The wide variation in DCAB-frequency in UC-associated dysplasia suggests potential biological differences between cases.
溃疡性结肠炎（UC）患者的活检常显示隐窝分支（CB）。
分析溃疡性结肠炎相关异型增生（D-UC）活检中 CB 的频率。
回顾性分析 49 例连续 D-UC 病例的数字化切片，并记录所有 CB。研究了性别、年龄、UC 病程、结直肠定位、上皮异型增生程度和黏膜样本/活检数量等潜在混杂因素。
49 例 D-UC 病例共记录了 334 个异型增生 CB（DCB）；321 个（96.1%）为非对称分支（DCAB），其余 13 个（3.9%）为对称分支（DCSB）。49 例 D-UC 病例中，41%有 1-4 个 DCAB，43%有 5-9 个 DCAB，10%有 10-15 个 DCAB，其余 6%有≥16 个 DCAB。49 例 D-UC 病例中，44 例（90%）存在低级别异型增生（LGD），5 例（10%）存在高级别异型增生（HGD）。DCAB 的频率不受年龄、性别、活检部位（右结肠、左结肠或直肠）、黏膜样本/活检数量、异型增生程度或 UC 病程的影响。
报道了两种新的 UC 相关异型增生的 DCB 组织学表型，即 DCAB 和 DCSB。UC 相关异型增生中 DCAB 频率的广泛差异表明病例之间可能存在潜在的生物学差异。
