Department of Pathology, Karolinska Institute, and University Hospital, Stockholm, Sweden;
Friedrich-Alexander-University Erlangen-Nuremberg, Bayreuth, Germany.
Anticancer Res. 2022 Sep;42(9):4493-4497. doi: 10.21873/anticanres.15950.
BACKGROUND/AIM: To report the frequency of crypts in asymmetric branching (CAB) in biopsies from all colorectal segments in patients with ulcerative colitis in remission (UCR).
Biopsies in 100 UC patients were investigated: 50 with UCR and 50 with ongoing long-lasting UC (LLU; i.e., controls).
The frequency of CAB was significantly lower in UCR than in LLUC, both in the right colon and left colorectum. CAB frequency was not influenced by two important confounders: the age and sex of patients.
CAB is a pathologic aberration of colorectal cryptogenesis evoked by chronic mucosal inflammation. When chronic inflammation waned in UCR, the production of CAB plummeted or ceased. Chronic inflammation and protracted disease-duration in LLUC increase the risk for colorectal dysplasia or carcinoma. Importantly, dysplastic CAB were recently detected in LLUC-associated dysplasia. Whether the abrogation of CAB is instrumental in reducing the neoplastic risk in UCR patients, deserves further investigation.
背景/目的：报告在缓解期（UCR）溃疡性结肠炎患者的所有结直肠段活检中，非对称分支（CAB）隐窝的频率。
对 100 例 UC 患者进行了研究：50 例为 UCR，50 例为持续性长期 UC（LLU；即对照组）。
UCR 中 CAB 的频率明显低于 LLUC，无论是在右结肠还是左结直肠。CAB 频率不受两个重要混杂因素的影响：患者的年龄和性别。
CAB 是慢性黏膜炎症引起的结直肠隐窝发生的病理异常。当 UCR 中的慢性炎症消退时，CAB 的产生急剧下降或停止。LLUC 中的慢性炎症和长期疾病持续时间增加了结直肠异型增生或癌的风险。重要的是，在 LLUC 相关异型增生中最近检测到异型 CAB。CAB 的消除是否有助于降低 UCR 患者的肿瘤风险，值得进一步研究。
