Rubio Carlos A, Vieth Michael, Lang-Schwarz Corinna
Department of Pathology, Karolinska Institute, and University Hospital, Stockholm, Sweden.
Friedrich-Alexander-University Erlangen-Nuremberg, Bayreuth, Germany.
Cancer Diagn Progn. 2022 May 3;2(3):305-307. doi: 10.21873/cdp.10109. eCollection 2022 May-Jun.
To report the detection of dysplastic crypts in asymmetric branching (DCAB) in biopsies from patients with ulcerative colitis (UC).
One hundred consecutive endoscopic biopsies from patients with UC undergoing surveillance were reviewed.
Three biopsy/cases showed DCAB. The frequency of DCAB varied from two in one case, three in another case, and five in the remaining case.
The final outcome of DCAB is to generate two or more dysplastic asymmetric offspring-crypts. Repeated DCAB offspring formation, together with new DCAB, would boost the pool of dysplastic crypts, resulting in an exponential expansion of the mucosal area occupied by dysplasia in UC.
报告在溃疡性结肠炎（UC）患者活检中检测到的不对称分支发育异常隐窝（DCAB）。
回顾了100例接受监测的UC患者的连续内镜活检样本。
3例活检样本显示有DCAB。DCAB的数量在1例中为2个，另1例中为3个，其余1例中为5个。
DCAB的最终结果是产生两个或更多发育异常的不对称子代隐窝。反复形成DCAB子代，再加上新的DCAB，会增加发育异常隐窝池，导致UC中发育异常所占据的黏膜面积呈指数级扩大。
