School of Sports Medicine and Health, Chengdu Sports University, Chengdu, China.
Department of Postpartum Rehabilitation, Sichuan Jinxin Women & Children Hospital, Chengdu, China.
Dev Neurobiol. 2022 Oct;82(7-8):625-638. doi: 10.1002/dneu.22905. Epub 2022 Nov 15.
Motor neuron disease (MND), including amyotrophic lateral sclerosis, spinal muscular atrophy and others, involved the upper or lower motor neurons selective loss, is characterized by neurodegeneration and neuroinflammation, in conjunction with microglia. We summarized that pathways and key mediators are associated with microglia, such as fractalkine signaling, purinergic signaling, NF-κB signaling, p38 MAPK signaling, TREM2-APOE signaling, ROCK signaling, C1q signaling, and Ion channel, which are involved in the activation, proliferation, and inflammation of microglia. This review aims to identify the microglia-related molecular target and explore potential treatment strategies for MND based on that target.
运动神经元病（MND），包括肌萎缩侧索硬化症、脊髓性肌萎缩症等，涉及上运动神经元或下运动神经元的选择性丧失，其特征是神经退行性变和神经炎症，同时伴有小胶质细胞。我们总结了与小胶质细胞相关的途径和关键介质，如 fractalkine 信号、嘌呤能信号、NF-κB 信号、p38 MAPK 信号、TREM2-APOE 信号、ROCK 信号、C1q 信号和离子通道，这些信号参与小胶质细胞的激活、增殖和炎症。本综述旨在确定小胶质细胞相关的分子靶点，并基于该靶点探索 MND 的潜在治疗策略。
