不依赖谷胱甘肽过氧化物酶4的铁死亡——疾病治疗的新策略。
GPX4-independent ferroptosis-a new strategy in disease's therapy.
作者信息
Ma Tianyu, Du Jingtong, Zhang Yufeng, Wang Yuyao, Wang Bingxuan, Zhang Tianhong
机构信息
Department of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, China.
Department of Reproductive Endocrinology, The Second Hospital affiliated to Harbin Medical University, Harbin, China.
出版信息
Cell Death Discov. 2022 Oct 30;8(1):434. doi: 10.1038/s41420-022-01212-0.
Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process. Ferroptosis plays an essential role in tumors, degenerative diseases, and ischemia-reperfusion injury. However, researchers have found that inhibition of GPX4 does not entirely suppress ferroptosis in certain diseases, or cells express resistance to ferroptosis agonists that inhibit GPX4. As research progresses, it has been discovered that there are multiple regulatory pathways for ferroptosis that are independent of GPX4. The study of GPX4-independent ferroptosis pathways can better target ferroptosis to prevent and treat various diseases. Here, the currently inhibited pulmonary GPX4-dependent ferroptosis pathways will be reviewed.
铁死亡是一种程序性细胞死亡形式，其特征在于细胞内铁积累和脂质过氧化，早期研究确定谷胱甘肽过氧化物酶4（GPX4）是这一过程的关键调节因子。铁死亡在肿瘤、退行性疾病和缺血再灌注损伤中起重要作用。然而，研究人员发现，在某些疾病中抑制GPX4并不能完全抑制铁死亡，或者细胞对抑制GPX4的铁死亡激动剂表现出抗性。随着研究的进展，人们发现铁死亡存在多种独立于GPX4的调节途径。对不依赖GPX4的铁死亡途径的研究可以更好地靶向铁死亡以预防和治疗各种疾病。在此，将对目前受抑制的肺GPX4依赖性铁死亡途径进行综述。
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