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Phospholipase iPLA2β acts as a guardian against ferroptosis.

作者信息

Mao Chao, Lei Guang, Zhuang Li, Gan Boyi

机构信息

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA.

出版信息

Cancer Commun (Lond). 2021 Nov;41(11):1082-1085. doi: 10.1002/cac2.12231. Epub 2021 Oct 17.

DOI:10.1002/cac2.12231
PMID:34657380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8626608/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1189/8626608/17994ff883cf/CAC2-41-1082-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1189/8626608/17994ff883cf/CAC2-41-1082-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1189/8626608/17994ff883cf/CAC2-41-1082-g001.jpg

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本文引用的文献

1
Mitochondrial regulation of ferroptosis.线粒体对铁死亡的调控。
J Cell Biol. 2021 Sep 6;220(9). doi: 10.1083/jcb.202105043. Epub 2021 Jul 30.
2
iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4.iPLA2β 介导的脂质解毒作用独立于 GPX4 控制由 p53 驱动的铁死亡。
Nat Commun. 2021 Jun 15;12(1):3644. doi: 10.1038/s41467-021-23902-6.
3
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.DHODH 介导的铁死亡防御是癌症的一个可靶向弱点。
乳房部分切除或全乳房切除术后女性的身体形象认知与生活质量调查：一项横断面研究
BMC Womens Health. 2025 Jul 10;25(1):342. doi: 10.1186/s12905-025-03898-7.
4
Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease.纳米材料介导的铁死亡调控在肾脏疾病中的应用
Int J Nanomedicine. 2025 Feb 5;20:1637-1659. doi: 10.2147/IJN.S496644. eCollection 2025.
5
The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy.铁死亡在结直肠癌中的作用及其与免疫治疗的潜在协同作用。
Front Immunol. 2025 Jan 9;15:1526749. doi: 10.3389/fimmu.2024.1526749. eCollection 2024.
6
Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives.铁死亡与心肌缺血再灌注：机制洞察与新的治疗前景
Front Pharmacol. 2024 Oct 1;15:1482986. doi: 10.3389/fphar.2024.1482986. eCollection 2024.
7
Current status and prospects of MOFs loaded with HO-related substances for ferroptosis therapy.用于铁死亡治疗的负载与羟基自由基（HO·）相关物质的金属有机框架材料的现状与展望
RSC Med Chem. 2024 Jun 27;15(9):2996-3016. doi: 10.1039/d4md00261j. eCollection 2024 Sep 19.
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Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells.过氧化物酶 6 抑制肺内皮细胞中的铁死亡。
Free Radic Biol Med. 2024 Jun;218:82-93. doi: 10.1016/j.freeradbiomed.2024.04.208. Epub 2024 Apr 3.
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Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12.
4
Phospholipase iPLAβ averts ferroptosis by eliminating a redox lipid death signal.磷酸酶 iPLAβ 通过消除氧化还原脂质死亡信号来避免铁死亡。
Nat Chem Biol. 2021 Apr;17(4):465-476. doi: 10.1038/s41589-020-00734-x. Epub 2021 Feb 4.
5
The Metabolic Underpinnings of Ferroptosis.铁死亡的代谢基础。
Cell Metab. 2020 Dec 1;32(6):920-937. doi: 10.1016/j.cmet.2020.10.011. Epub 2020 Nov 19.
6
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.辅酶 Q 氧化还原酶 FSP1 与 GPX4 平行作用以抑制铁死亡。
Nature. 2019 Nov;575(7784):688-692. doi: 10.1038/s41586-019-1705-2. Epub 2019 Oct 21.
7
FSP1 is a glutathione-independent ferroptosis suppressor.FSP1 是一种谷胱甘肽不依赖的铁死亡抑制因子。
Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21.
8
BAP1 links metabolic regulation of ferroptosis to tumour suppression.BAP1 将铁死亡代谢调控与肿瘤抑制联系起来。
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9
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10
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Aging (Albany NY). 2017 Oct 28;9(10):2137-2162. doi: 10.18632/aging.101306.