Klesh K W, Murphy T F, Scher M S, Buchanan D E, Maxwell E P, Guthrie R D
Am J Dis Child. 1987 Aug;141(8):852-7. doi: 10.1001/archpedi.1987.04460080038023.
Persistent pulmonary hypertension of the newborn and its attendant hypoxemia may place the infant at high risk for hypoxic-ischemic injury. In 19 infants with persistent pulmonary hypertension of the newborn, 16 of whom suffered intrapartum asphyxia, we evaluated a series of electroencephalograms (EEGs) for evidence of major focal cerebral injury, ie, persistent voltage attenuation and/or focal electrical-seizure activity. Of the 15 infants (78.9%) with such EEG findings, nine infants (47% of the total population) had cerebral infarction documented by cranial sonograms, computed tomographic scans, or autopsy findings. In eight (89%) of the nine infants with infarction, electrical seizures were noted during periods of muscle paralysis. We recommend (1) the use of electroencephalography in this population, particularly during periods of muscle paralysis, to detect underlying cerebrovascular lesions and (2) the use of cranial computed tomography if persistent, focal EEG abnormalities are noted.
新生儿持续性肺动脉高压及其伴随的低氧血症可能使婴儿面临缺氧缺血性损伤的高风险。在19例新生儿持续性肺动脉高压患儿中，其中16例在分娩时发生窒息，我们评估了一系列脑电图（EEG），以寻找严重局灶性脑损伤的证据，即持续性电压衰减和/或局灶性癫痫样放电活动。在15例（78.9%）有此类EEG表现的婴儿中，9例婴儿（占总人数的47%）经头颅超声、计算机断层扫描或尸检结果证实有脑梗死。在9例梗死婴儿中的8例（89%），在肌肉麻痹期间记录到癫痫样放电。我们建议：（1）对这一人群使用脑电图检查，尤其是在肌肉麻痹期间，以检测潜在的脑血管病变；（2）如果发现持续性、局灶性EEG异常，则使用头颅计算机断层扫描。
