口服锌作为寻常痤疮中系统性异维A酸的新型辅助和节约疗法：一项初步比较研究。
Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study.
作者信息
Salah Eman
机构信息
Dr. Salah is an Assistant Professor of Dermatology, Venereology and Andrology at Zagazig University in Zagazig, Egypt.
出版信息
J Clin Aesthet Dermatol. 2022 Oct;15(10):58-61.
BACKGROUND
Systemic isotretinoin is the most effective treatment for acne vulgaris (AV). However, numerous side effects are associated with isotretinoin. Oral zinc has a better safety profile and has been used to treat AV with variable results.
OBJECTIVE
We sought to evaluate the safety and efficacy of combining oral zinc to low-dose systemic isotretinoin in AV patients.
METHODS
Sixty AV patients were divided into two groups. Group A received oral zinc sulfate plus low-dose isotretinoin and Group B received the standard isotretinoin dosage. At each visit acne severity, photos, side effects, and patient-reported satisfaction were recorded.
RESULTS
In the two groups, no significant difference in reduction of lesion count and Global Acne Grading System scores. The frequency of treatment-related side effects was (20%) in Group A and (76.7%) in Group B. Furthermore, there was no difference regarding the relapse rates between both groups (>0.05). Finally, the patients' satisfaction rates did not differ between the two groups.
CONCLUSION
Oral zinc plus low-dose isotretinoin resulted in satisfactory improvement in AV patients with fewer side effects. Further studies are recommended to compare the efficacy of other zinc preparations if combined with systemic isotretinoin at different concentrations.
背景
系统性异维A酸是治疗寻常痤疮（AV）最有效的方法。然而，异维A酸有许多副作用。口服锌安全性更好，已用于治疗AV，但效果不一。
目的
我们试图评估在AV患者中联合口服锌与低剂量系统性异维A酸的安全性和有效性。
方法
60例AV患者分为两组。A组接受口服硫酸锌加低剂量异维A酸，B组接受标准剂量异维A酸。每次就诊时记录痤疮严重程度、照片、副作用及患者报告的满意度。
结果
两组在皮损计数减少和全球痤疮分级系统评分方面无显著差异。A组治疗相关副作用发生率为20%，B组为76.7%。此外，两组复发率无差异（>0.05）。最后，两组患者满意度无差异。
结论
口服锌加低剂量异维A酸可使AV患者获得满意改善，且副作用较少。建议进一步研究比较其他锌制剂与不同浓度系统性异维A酸联合使用的疗效。
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