Ding Rui-Lian, Zheng Yu, Bu Jin
Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Jul 18;16:1843-1854. doi: 10.2147/CCID.S416267. eCollection 2023.
Isotretinoin (ISO) is a powerful vitamin A derivative that offers the potential for treatment of permanent remission of acne; however, its potential side effects on both physiological and psychological aspects limit its application. This article reviews the side effects of ISO from physiological and psychological aspects in detail, to better screen the suitable population of ISO and improve the efficiency of clinical treatment. Our findings indicate that ISO may cause teratogenicity, skin reactions, ocular reactions, changes in blood indicators, and occasional acne fulminans. To optimize clinical treatment, more attention should be paid to identifying the specific conditions under which these reactions occur, how severe they are, and how they subside to alleviate patient concerns. Regarding the controversial issue of psychological side effects caused by ISO, researchers should shift their focus to the psychological problems that acne itself may cause.
异维A酸（ISO）是一种强效的维生素A衍生物，具有实现痤疮永久性缓解治疗的潜力；然而，其在生理和心理方面的潜在副作用限制了其应用。本文详细综述了异维A酸在生理和心理方面的副作用，以更好地筛选异维A酸的合适适用人群并提高临床治疗效率。我们的研究结果表明，异维A酸可能会导致致畸性、皮肤反应、眼部反应、血液指标变化，以及偶尔出现的暴发性痤疮。为优化临床治疗，应更加关注识别这些反应发生的具体情况、严重程度以及消退方式，以减轻患者的担忧。关于异维A酸引起的心理副作用这一有争议的问题，研究人员应将重点转向痤疮本身可能导致的心理问题。
