从细胞尺度微管向脑细胞外间隙进行扩散性药物递送。
Diffusive drug delivery in the brain extracellular space from a cellular scale microtube.
作者信息
Störi Marie-Joe, Oluwasanya Pelumi W, Proctor Christopher M
机构信息
Engineering Department, University of Cambridge, Cambridge, UK.
出版信息
MRS Commun. 2022;12(5):654-661. doi: 10.1557/s43579-022-00247-9. Epub 2022 Sep 19.
UNLABELLED
The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. The influence of flow rate, drug properties and device geometry are investigated. It is anticipated that these findings will accelerate progress on both developmental and applied drug delivery and materials research.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1557/s43579-022-00247-9.
未标注
用于治疗神经系统疾病的先进全身治疗方法的有效性不仅受到血脑屏障穿透困难的阻碍，还受到脱靶药物相互作用的影响。在本研究中，模拟了一种新型U形微管的给药方法，该微管将药物直接局部注入脑的细胞外空间，并依靠扩散作为转运机制。研究了流速、药物性质和装置几何形状的影响。预计这些发现将加速药物递送和材料研究在开发和应用方面的进展。
补充信息
在线版本包含可在10.1557/s43579-022-00247-9获取的补充材料。
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