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通过功能印迹胶束检测严重急性呼吸综合征冠状病毒2(SARS-CoV-2)

Detection of SARS-COV-2 by functionally imprinted micelles.

作者信息

Hubbard Lance R, Allen Caleb J, Sims Amy C, Engbrecht Kristin M, O'Hara Matthew J, Johnson Jared C, Morrison Samuel S

机构信息

Pacific Northwest National Laboratory, Richland, Washington, DC USA.

出版信息

MRS Commun. 2022;12(6):1160-1167. doi: 10.1557/s43579-022-00242-0. Epub 2022 Oct 25.

Abstract

UNLABELLED

The near real-time detection of airborne particles-of-interest is needed for avoiding current/future threats. The incorporation of imprinted particles into a micelle-based electrochemical cell produced a signal when brought into contact with particle analytes (such as SARS-COV-2), previously imprinted onto the structure. Nanoamp scales of signals were generated from what may've been individual virus-micelle interactions. The system showed selectivity when tested against similar size and morphology particles. The technology was compatible with airborne aerosol sampling techniques. Overall, the application of imprinted micelle technology could provide near real-time detection methods to a host of possible analytes of interest in the field.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1557/s43579-022-00242-0.

摘要

未标注

为避免当前/未来威胁,需要对空气中感兴趣的颗粒进行近实时检测。将印迹颗粒掺入基于胶束的电化学电池中,当与先前印刻在结构上的颗粒分析物(如SARS-CoV-2)接触时会产生信号。纳米安培级别的信号可能来自单个病毒-胶束相互作用。该系统在针对类似大小和形态的颗粒进行测试时显示出选择性。该技术与空气气溶胶采样技术兼容。总体而言,印迹胶束技术的应用可为该领域中许多可能感兴趣的分析物提供近实时检测方法。

补充信息

在线版本包含可在10.1557/s43579-022-00242-0获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce39/9592882/134426709068/43579_2022_242_Fig1_HTML.jpg

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