Su Qi, Ng Wei Lun, Goh Suh Yee, Gulam Muhammad Yaaseen, Wang Lin-Fa, Tan Eng-King, Ahn Matae, Chao Yin-Xia
Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Department of Neurology, Singapore General Hospital, Singapore, Singapore.
Front Aging Neurosci. 2022 Oct 12;14:957705. doi: 10.3389/fnagi.2022.957705. eCollection 2022.
Parkinson's disease (PD) is one of the most common neurodegenerative diseases in which neuroinflammation plays pivotal roles. An important mechanism of neuroinflammation is the NLRP3 inflammasome activation that has been implicated in PD pathogenesis. In this perspective, we will discuss the relationship of some key PD-associated proteins including α-synuclein and Parkin and their contribution to inflammasome activation. We will also review promising inhibitors of NLRP3 inflammasome pathway that have potential as novel PD therapeutics. Finally, we will provide a summary of current and potential and models that are available for therapeutic discovery and development.
帕金森病（PD）是最常见的神经退行性疾病之一，神经炎症在其中起着关键作用。神经炎症的一个重要机制是NLRP3炎性小体激活，这与PD发病机制有关。从这个角度出发，我们将讨论一些与PD相关的关键蛋白质，包括α-突触核蛋白和帕金森蛋白之间的关系，以及它们对炎性小体激活的作用。我们还将综述有前景的NLRP3炎性小体途径抑制剂，这些抑制剂有潜力成为新型PD治疗药物。最后，我们将总结目前可用于治疗发现和开发的现有及潜在模型。
