咖啡因预处理对电休克治疗的促进作用。

Facilitation of ECT by caffeine pretreatment.

作者信息

Shapira B, Lerer B, Gilboa D, Drexler H, Kugelmass S, Calev A

出版信息

Am J Psychiatry. 1987 Sep;144(9):1199-202. doi: 10.1176/ajp.144.9.1199.

DOI:10.1176/ajp.144.9.1199

Abstract

In this study, eight patients participated in a standardized protocol to assess the effects of caffeine on seizures in ECT. Caffeine sodium benzoate (500-2000 mg) was administered intravenously 10 minutes before ECT, and seizure duration was compared with that of a previous treatment unmodified by caffeine. Seizure duration was significantly increased during ECTs preceded by caffeine. Three other patients given caffeine when seizures of adequate duration could no longer be elicited at maximal stimulus levels experienced longer seizures. Administration of caffeine was not associated with significant cardiovascular or other (including cognitive) adverse effects.

摘要

在本研究中，八名患者参与了一项标准化方案，以评估咖啡因对电休克治疗（ECT）中癫痫发作的影响。在ECT前10分钟静脉注射苯甲酸钠咖啡因（500 - 2000毫克），并将癫痫发作持续时间与之前未用咖啡因治疗时进行比较。在注射咖啡因后的ECT过程中，癫痫发作持续时间显著延长。另外三名患者在最大刺激水平下无法引发足够持续时间的癫痫发作时给予咖啡因，其癫痫发作持续时间更长。使用咖啡因未出现明显的心血管或其他（包括认知方面）不良反应。