Coffey C E, Figiel G S, Weiner R D, Saunders W B
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
Am J Psychiatry. 1990 May;147(5):579-85. doi: 10.1176/ajp.147.5.579.
In a randomized, double-blind, placebo-controlled pilot study of 40 depressed inpatients, the authors compared two techniques for maintaining seizure duration during pulse unilateral ECT: pretreatment with intravenous caffeine versus electrical stimulus intensity dosing. Both techniques effectively maintained seizure duration, but with caffeine this was accomplished without any increase in mean stimulus intensity over the course of ECT. There were no differences between the two techniques in therapeutic outcome or cognitive side effects from ECT, and caffeine pretreatment was well tolerated. The authors discuss the clinical and research implications of these findings with respect to strategies for maintaining seizure duration during ECT.
在一项针对40名住院抑郁症患者的随机、双盲、安慰剂对照试验性研究中，作者比较了在单侧脉冲式电休克治疗（ECT）期间维持癫痫发作时长的两种技术：静脉注射咖啡因预处理与电刺激强度给药。两种技术均能有效维持癫痫发作时长，但使用咖啡因时，在ECT过程中平均刺激强度并未增加。两种技术在治疗效果或ECT的认知副作用方面没有差异，且咖啡因预处理耐受性良好。作者讨论了这些发现对于ECT期间维持癫痫发作时长策略的临床及研究意义。
