调整后的新冠病毒加强针接种计划平衡了抗体滴度中与年龄相关的差异，使高危人群受益。
Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations.
作者信息
Müller Lisa, Andrée Marcel, Moskorz Wiebke, Drexler Ingo, Hauka Sandra, Ptok Johannes, Walotka Lara, Grothmann Ramona, Hillebrandt Jonas, Ritchie Anastasia, Peter Laura, Walker Andreas, Timm Jörg, Adams Ortwin, Schaal Heiner
机构信息
Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
出版信息
Front Aging. 2022 Oct 12;3:1027885. doi: 10.3389/fragi.2022.1027885. eCollection 2022.
We provide follow-up data on the humoral immune response after COVID-19 vaccinations of two distinct cohorts aged below 60 and over 80 years to screen for age-related differences in the longevity and magnitude of the induction of the antibody responses post booster-vaccinations. While anti-SARS-CoV-2 spike-specific IgG and neutralization capacity waned rapidly after the initial vaccination schedule, additional boosters highly benefitted the humoral immune responses especially in the elderly cohort, including the neutralization of Omikron variants. Thus, adjusted COVID-19 booster vaccination schedules are an appropriate tool to overcome limitations in the success of vaccinations.
我们提供了两个不同队列（年龄在60岁以下和80岁以上）接种新冠疫苗后体液免疫反应的随访数据，以筛查加强免疫接种后抗体反应诱导的持久性和强度方面与年龄相关的差异。虽然在初始接种程序后，抗SARS-CoV-2刺突特异性IgG和中和能力迅速下降，但额外的加强针显著有益于体液免疫反应，尤其是在老年队列中，包括对奥密克戎变体的中和。因此，调整后的新冠加强免疫接种程序是克服疫苗接种成功局限性的合适工具。
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