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肽ILE-GLU-TRP（Stemokin）：刺激平衡免疫反应的潜在佐剂

Peptide ILE-GLU-TRP (Stemokin) Potential Adjuvant Stimulating a Balanced Immune Response.

作者信息

Deigin Vladislav, Koroev Dmitry, Volpina Olga

机构信息

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.

Immunotech developments Inc, 2395 Speakman Drive, Suite 2025, L5K 1B3 Mississauga, ON Canada.

出版信息

Int J Pept Res Ther. 2022;28(6):156. doi: 10.1007/s10989-022-10461-7. Epub 2022 Oct 21.

DOI:10.1007/s10989-022-10461-7
PMID:36313476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9589648/
Abstract

Vaccines are widely used worldwide to prevent and protect from various infections. A variety of modern approaches to developing prophylactic and therapeutic vaccines is growing. In almost all cases, adjuvants are necessary to obtain an effective immune response.This work investigated the possibility of using the pharmaceutical peptide drug Stemokin as an adjuvant stimulating a balanced Th1/Th2 response.A study was conducted to compare the activity of Stemokin versus the approved adjuvant Alhydrogel in a murine vaccination model with the approved VAXIGRIP® vaccine.The first proof-of-concept experimental study shows that the peptide Ile-Glu-Trp has the adjuvant vaccine properties and anti-HA IgG2a enhancing response, revealing a Th1- favoring balanced Th1/Th2 immunomodulation.

摘要

疫苗在全球范围内被广泛用于预防和抵御各种感染。开发预防性和治疗性疫苗的各种现代方法不断涌现。几乎在所有情况下，都需要佐剂来获得有效的免疫反应。这项工作研究了使用药物肽类药物Stemokin作为刺激平衡的Th1/Th2反应的佐剂的可能性。进行了一项研究，在使用已获批准的VAXIGRIP®疫苗的小鼠疫苗接种模型中比较Stemokin与已获批准的佐剂氢氧化铝的活性。首个概念验证实验研究表明，肽Ile-Glu-Trp具有佐剂疫苗特性和增强抗HA IgG2a反应，揭示了偏向Th1的平衡Th1/Th2免疫调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/e8b2efb0d49b/10989_2022_10461_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/8555a9fc6115/10989_2022_10461_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/b5249e979494/10989_2022_10461_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/e8b2efb0d49b/10989_2022_10461_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/8555a9fc6115/10989_2022_10461_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/b5249e979494/10989_2022_10461_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3317/9589648/e8b2efb0d49b/10989_2022_10461_Fig1_HTML.jpg

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